The role of PAI-1 4G/5G polymorphism in venous thrombosis is unclear. PAI-1 4G/4G genotype is associated with elevated levels of PAI-1 resulting in a hypofibrinolytic state and hence increased thrombotic risk. In this study, we assessed the role of PAI-1 4G/5G promoter polymorphism in adult patients with splanchnic vein thrombosis. A total of 40 cases (portal vein thrombosis and Budd-Chiari syndrome) and 40 healthy controls were evaluated for the PAI-1 4G/5G polymorphism by amplification refractory mutation system polymerase chain reaction along with thrombophilia workup. The frequency of PAI-1 4G/4G homozygous, 4G/5G heterozygous and 5G/5G homozygous genotypes were 17.5%, 42.5% and 40%, respectively among cases and 22.5%, 50% and 27.5%, respectively among controls and the difference was not statistically significant (p = 0.61). The PAI-1 4G/4G genotype was significantly associated with the cases with deranged thrombophilic risk factor (both inherited and acquired) (p = 0.02).

PAI-1 4G/5G多态性在静脉血栓形成中的作用尚不清楚。PAI-1 4G/4G 基因型与 PAI-1 水平升高相关，导致低纤维蛋白溶解状态，从而增加血栓形成风险。在这项研究中，我们评估了PAI-1 4G/5G启动子多态性在成年内脏静脉血栓形成患者中的作用。共评估了 40 例（门静脉血栓形成和布-加综合征）和 40 名健康对照的PAI-1 4G/5G通过扩增难治性突变系统聚合酶链反应以及易栓症检查来确定多态性。PAI-1 4G/4G纯合子、4G/5G杂合子和5G/5G纯合子基因型频率在病例中分别为17.5%、42.5%和40%，在对照组中分别为22.5%、50%和27.5%，差异没有统计学意义 ( p  = 0.61)。PAI-1 4G/4G 基因型与具有异常血栓形成倾向危险因素（遗传性和获得性）的病例显着相关 ( p  = 0.02)。