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Neurophysiological correlates of disorder-related autobiographical memory in anorexia nervosa
Psychological Medicine ( IF 6.9 ) Pub Date : 2021-06-18 , DOI: 10.1017/s003329172100221x
Valentin Terhoeven 1 , Christoph Nikendei 1 , Sandra Faschingbauer 1 , Julia Huber 1 , Kymberly D Young 2 , Martin Bendszus 3 , Wolfgang Herzog 1 , Hans-Christoph Friederich 1 , Joe J Simon 1
Affiliation  

Background

Anorexia nervosa (AN) is characterized by an overgeneralization of food/body-related autobiographical memories (AM). This is regarded as an emotion regulation strategy with adverse long-term effects implicated in disorder maintenance and treatment resistance. Therefore, we aimed to examine neural correlates of food/body-related AM-recall in AN.

Methods

Twenty-nine female patients with AN and 30 medication-free age-sex-matched normal-weight healthy controls (HC) underwent functional magnetic resonance imaging while recalling AMs in response to food/body-related and neutral cue words. To control for general knowledge retrieval, participants engaged in a semantic generation and riser detection task.

Results

In comparison to HC, patients with AN generated fewer and less specific AMs in response to food/body-related words, but not for neutral cue words. Group comparisons revealed reduced activation in regions associated with self-referential processing and memory retrieval (precuneus and angular gyrus) during the retrieval of specific food/body-related AM in patients with AN. Brain connectivity in regions associated with memory functioning and executive control was reduced in patients with AN during the retrieval of specific food/body-related AM. Finally, resting-state functional connectivity analysis revealed no differences between groups, arguing against a general underlying disconnection of brain networks implicated in memory and emotional processing in AN.

Conclusions

These results indicate impaired neural processing of food/body-related AM in AN, with a reduced involvement of regions involved in self-referential processing. Our findings are discussed as possible neuronal correlates of emotional avoidance in AN and provide new insights of AN-pathophysiology underscoring the importance of targeting dysfunctional emotion regulation strategies during treatment.



中文翻译:

神经性厌食症中与疾病相关的自传体记忆的神经生理学相关性

背景

神经性厌食症 (AN) 的特征是过度概括食物/身体相关的自传体记忆 (AM)。这被认为是一种情绪调节策略,具有与疾病维持和治疗抵抗有关的不利长期影响。因此,我们旨在检查 AN 中与食物/身体相关的 AM 回忆的神经相关性。

方法

29 名患有 AN 的女性患者和 30 名年龄性别匹配的正常体重健康对照 (HC) 接受了功能性磁共振成像,同时回忆 AMs 以响应食物/身体相关和中性提示词。为了控制一般知识检索,参与者参与了语义生成和提升检测任务。

结果

与 HC 相比,AN 患者对食物/身体相关词的反应产生越来越少的特异性 AM,但对中性提示词则没有。组比较显示,在 AN 患者检索特定食物/身体相关 AM 期间,与自我参照处理和记忆检索(楔前叶和角回)相关的区域的激活减少。在检索特定食物/身体相关 AM 期间,AN 患者与记忆功能和执行控制相关的区域的大脑连接性降低。最后,静息态功能连通性分析显示各组之间没有差异,反驳了 AN 中涉及记忆和情绪处理的大脑网络普遍存在的潜在断开。

结论

这些结果表明 AN 中与食物/身体相关的 AM 的神经处理受损,参与自我参照处理的区域减少。我们的研究结果被讨论为 AN 中情绪回避的可能神经元相关因素,并提供了 AN 病理生理学的新见解,强调了在治疗期间针对功能失调的情绪调节策略的重要性。

更新日期:2021-06-18
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