Periodontitis would cause dental tissue damage locally. Biomaterials substantially affect the surrounding immune microenvironment through treatment-oriented local inflammatory remodeling in dental periodontitis. This remodeling process is conducive to wound healing and periodontal tissue regeneration. Recent progress in understanding the foreign body response (FBR) and immune regulation, including cell heterogeneity, and cell-cell and cell-material interactions, has provided new insights into the design criteria for biomaterials applied in treatment of periodontitis. This review discusses recent progress and perspectives in the immune regulation effects of biomaterials to augment or reconstruct soft and hard tissue in an inflammatory microenvironment of periodontitis.

中文翻译：

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生物材料在牙周炎炎症存在下通过异物反应在牙周组织修复和重建中的应用：近期进展与展望

牙周炎会导致局部牙齿组织损伤。生物材料通过治疗牙周炎的局部炎症重塑显着影响周围的免疫微环境。这种重塑过程有利于伤口愈合和牙周组织再生。最近在了解异物反应 (FBR) 和免疫调节方面取得的进展，包括细胞异质性，以及细胞-细胞和细胞-材料相互作用，为用于治疗牙周炎的生物材料的设计标准提供了新的见解。本综述讨论了生物材料在牙周炎炎性微环境中增强或重建软硬组织的免疫调节作用的最新进展和展望。