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Immunoregulation by antibody secreting cells in inflammation, infection, and cancer
Immunological Reviews ( IF 8.7 ) Pub Date : 2021-06-17 , DOI: 10.1111/imr.12991
Shannon E McGettigan 1 , Gudrun F Debes 1, 2
Affiliation  

Antibody-secreting cells (ASCs) are considered work horses of the humoral immune response for their tireless effort to produce large amounts of antibodies that fulfill an array of functions in host defense, inflammation, and maintenance of homeostasis. While traditionally considered largely senescent cells, surprising recent findings demonstrate that subsets of ASCs downmodulate ongoing immune responses independent of antibody formation. Such regulatory ASCs produce IL-10 or IL-35 and are implicated in maintaining tissue and immune homeostasis. They also serve to suppress pathogenic leukocytes in infection, allergy, and inflammatory diseases that affect tissues, such as the central nervous system and the respiratory tract. Additionally, regulatory ASCs infiltrate various cancer types and restrict effective anti-tumor T cell responses. While incompletely understood, there is significant overlap in factors that control ASC differentiation, IL-10 expression by B cells and the generation of ASCs that secrete both antibodies and IL-10. In this review, we will cover the biology, phenotype, generation, maintenance and function of regulatory ASCs in various tissues under pathological and steady states. An improved understanding of the development of regulatory ASCs and their biological roles will be critical for generating novel ASC-targeted therapies for the treatment of inflammatory diseases, infection, and cancer.

中文翻译:

抗体分泌细胞在炎症、感染和癌症中的免疫调节

抗体分泌细胞 (ASC) 被认为是体液免疫反应的工作马,因为它们不懈地努力产生大量抗体,这些抗体在宿主防御、炎症和维持体内平衡方面发挥着一系列功能。虽然传统上被认为主要是衰老细胞,但最近令人惊讶的发现表明,ASCs 的亚群下调正在进行的免疫反应,而与抗体形成无关。这种调节性 ASC 产生 IL-10 或 IL-35,并与维持组织和免疫稳态有关。它们还用于抑制感染、过敏和影响组织(如中枢神经系统和呼吸道)的炎症性疾病中的致病性白细胞。此外,调节性 ASC 浸润各种癌症类型并限制有效的抗肿瘤 T 细胞反应。虽然不完全了解,但控制 ASC 分化的因素、B 细胞的 IL-10 表达和分泌抗体和 IL-10 的 ASC 的产生存在显着重叠。在这篇综述中,我们将涵盖病理和稳态下各种组织中调节性 ASC 的生物学、表型、生成、维持和功能。更好地理解调节性 ASC 的发展及其生物学作用对于产生新的 ASC 靶向疗法来治疗炎症性疾病、感染和癌症至关重要。病理和稳态下各种组织中调节性 ASCs 的维持和功能。更好地理解调节性 ASC 的发展及其生物学作用对于产生新的 ASC 靶向疗法来治疗炎症性疾病、感染和癌症至关重要。病理和稳态下各种组织中调节性 ASCs 的维持和功能。更好地理解调节性 ASC 的发展及其生物学作用对于产生新的 ASC 靶向疗法来治疗炎症性疾病、感染和癌症至关重要。
更新日期:2021-08-24
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