To evaluate the effects of isometric handgrip exercise training (IHET) on blood pressure and heart rate variability in hypertensive subjects. Five databases were searched for randomized clinical trials in English, Spanish, or Portuguese evaluating the effect of IHET vs. no exercise on blood pressure (systolic and/or diastolic) and/or heart rate variability (low frequency [LF], high frequency [HF], and/or LF/HF ratio) through December 2020. Random-effects meta-analyses of mean differences (MDs) and/or standardized mean differences (SMDs) with 95% confidence intervals (CIs) were performed. Five trials were selected (n = 324 hypertensive subjects), whose durations ranged from 8 to 10 weeks. Compared to no exercise, IHET reduced systolic blood pressure (MD −8.11 mmHg, 95% CI −11.7 to −4.53, p < 0.001) but did not affect diastolic blood pressure (MD −2.75 mmHg, 95% CI −9.47–3.96, p = 0.42), LF (SMD −0.14, 95% CI −0.65–0.37, p = 0.59), HF (SMD 0.38, 95% CI −0.14–0.89, p = 0.15), or the LF/HF ratio (SMD −0.22, 95% CI −0.95–0.52, p = 0.57). IHET performed for 8–10 weeks had a positive effect on resting systolic blood pressure but did not interfere with diastolic blood pressure or heart rate variability in hypertensive subjects. These data should be interpreted with caution since all volunteers included in the studies were clinically medicated and their blood pressure was controlled.

评估等长握力运动训练 (IHET) 对高血压受试者的血压和心率变异性的影响。在五个数据库中搜索了英语、西班牙语或葡萄牙语的随机临床试验，以评估 IHET 与不运动对血压（收缩压和/或舒张压）和/或心率变异性（低频 [LF]、高频 [ HF] 和/或 LF/HF 比率）到 2020 年 12 月。对均值差 (MD) 和/或标准化均值差 (SMD) 和 95% 置信区间 (CI) 进行了随机效应荟萃分析。选择了五项试验（n  = 324 名高血压受试者），其持续时间从 8 到 10 周不等。与不运动相比，IHET 降低了收缩压（MD -8.11 mmHg，95% CI -11.7 至 -4.53，p < 0.001) 但不影响舒张压（MD -2.75 mmHg，95% CI -9.47-3.96，p  = 0.42），LF（SMD -0.14，95% CI -0.65-0.37，p  = 0.59），HF（ SMD 0.38, 95% CI -0.14–0.89, p  = 0.15), 或 LF/HF 比率 (SMD -0.22, 95% CI -0.95–0.52, p  = 0.57)。进行 8-10 周的 IHET 对静息收缩压有积极影响，但不会干扰高血压受试者的舒张压或心率变异性。应谨慎解释这些数据，因为研究中的所有志愿者都接受了临床药物治疗，并且他们的血压得到了控制。