Approximately 1.6 million patients in the United States are affected by tricuspid valve regurgitation, which occurs when the tricuspid valve does not close properly to prevent backward blood flow into the right atrium. Despite its critical role in proper cardiac function, the tricuspid valve has received limited research attention compared to the mitral and aortic valves on the left side of the heart. As a result, proper valvular function and the pathologies that may cause dysfunction remain poorly understood. To promote further investigations of the biomechanical behavior and response of the tricuspid valve, this work establishes a parameter-based approach that provides a template for tricuspid valve modeling and simulation. The proposed tricuspid valve parameterization presents a comprehensive description of the leaflets and the complex chordae tendineae for capturing the typical three-leaflet structural deformation observed from medical data. This simulation framework develops a practical procedure for modeling tricuspid valves and offers a robust, flexible approach to analyze the performance and effectiveness of various valve configurations using isogeometric analysis. The proposed methods also establish a baseline to examine the tricuspid valve’s structural deformation, perform future investigations of native valve configurations under healthy and disease conditions, and optimize prosthetic valve designs.

在美国，大约有 160 万患者受到三尖瓣反流的影响，这种情况发生在三尖瓣未正确关闭以防止血液倒流进入右心房时。尽管三尖瓣在适当的心脏功能中起着关键作用，但与心脏左侧的二尖瓣和主动脉瓣相比，三尖瓣受到的研究关注有限。因此，正常的瓣膜功能和可能导致功能障碍的病理学仍然知之甚少。促进对生物力学行为的进一步研究和三尖瓣的响应，这项工作建立了一种基于参数的方法，为三尖瓣建模和仿真提供了模板。拟议的三尖瓣参数化提供了对小叶和复杂腱索的全面描述，用于捕获从医学数据中观察到的典型三叶结构变形。该仿真框架开发了一个用于对三尖瓣进行建模的实用程序，并提供了一种稳健、灵活的方法来使用等几何分析来分析各种瓣膜配置的性能和有效性。所提出的方法还建立了一个基线来检查三尖瓣的结构变形，对健康和疾病条件下的天然瓣膜配置进行未来调查，并优化人工瓣膜设计。