Rationale

Misuse of dextroamphetamine occurs in work and recreational contexts. While acute drug effects broadly predict abuse liability, few studies have considered the relationship between acute effects and context.

Objectives

This study examined how individual differences in acute effects of dextroamphetamine relate to desire to take dextroamphetamine again in different contexts.

Methods

This secondary analysis used data from healthy adults with no history of moderate-to-severe substance use disorder, who received oral doses of placebo and dextroamphetamine (10 and 20 mg) over 3 sessions under double-blind, randomized conditions. Subjects rated subjective effects and completed reward-related behavioral tasks. Subjects rated their desire to take dextroamphetamine again in hypothetical work and recreational contexts. Multilevel models examined within-subjects change scores (10 mg-placebo; 20 mg-placebo) to determine how subjective effects and behavioral outcomes predicted desire to take dextroamphetamine again for work versus recreation.

Results

Subjects reported more desire to take 20 mg dextroamphetamine again for work than for recreation. At 20 mg, there was an interaction between context and liking/wanting, such that liking/wanting predicted desire to use dextroamphetamine for work only. There was also an interaction at 20 mg between context and psychomotor speed, such that psychomotor speed predicted interest in using dextroamphetamine for recreation only.

Conclusions

We found that positive subjective effects predicted desire to use dextroamphetamine again for work, while increased motor effects predicted desire to use dextroamphetamine recreationally. Hedonic effects may be perceived as advantageous when working, while increased physical energy may be preferred during recreation, suggesting that context of intended use is important when examining abuse liability.

中文翻译：

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急性药物作用不同地预测再次服用右旋苯丙胺工作和娱乐的愿望

基本原理

右旋苯丙胺的滥用发生在工作和娱乐环境中。虽然急性药物效应广泛预测滥用倾向，但很少有研究考虑急性效应和背景之间的关系。

目标

本研究探讨了右旋苯丙胺急性作用的个体差异与在不同情况下再次服用右旋苯丙胺的愿望之间的关系。

方法

该次要分析使用了来自没有中度至重度物质使用障碍病史的健康成年人的数据，他们在双盲、随机条件下接受了 3 次口服剂量的安慰剂和右旋安非他明（10 和 20 毫克）。受试者对主观效果进行评分并完成与奖励相关的行为任务。受试者评估他们在假设的工作和娱乐环境中再次服用右旋苯丙胺的愿望。多级模型检查了受试者内部的变化分数（10 毫克安慰剂；20 毫克安慰剂），以确定主观影响和行为结果如何预测再次服用右旋安非他明工作与娱乐的愿望。

结果

受试者报告更希望再次服用 20 毫克右旋苯丙胺用于工作而不是用于娱乐。在 20 毫克时，情境和喜欢/想要之间存在相互作用，因此喜欢/想要预测仅使用右旋安非他明工作的愿望。在 20 mg 时，情境和精神运动速度之间也存在相互作用，因此精神运动速度预测了人们对仅将右旋安非他明用于娱乐的兴趣。

结论

我们发现，积极的主观影响预测了再次使用右旋苯丙胺工作的愿望，而增加的运动效果预测了休闲使用右旋苯丙胺的愿望。享乐效应在工作时可能被认为是有利的，而在娱乐期间可能更喜欢增加体力，这表明在检查滥用责任时，预期用途的背景很重要。