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Epigenetic modulation of the tumor microenvironment in head and neck cancer: Challenges and opportunities
Critical Reviews in Oncology/Hematology ( IF 6.2 ) Pub Date : 2021-06-17 , DOI: 10.1016/j.critrevonc.2021.103397
Erison Santana Dos Santos 1 , Vivian Petersen Wagner 2 , Joab Cabral Ramos 1 , Daniel W Lambert 2 , Rogerio Moraes Castilho 3 , Adriana Franco Paes Leme 4
Affiliation  

Head and neck cancer is globally challenging due to the resistance to therapy and aggressive behavior leading to high rates of mortality. Recent findings show that the tumor microenvironment plays a role in the maintenance and progression of many solid tumors, including head and neck cancer. The mechanisms involved in the modulation and regulation of the tumor microenvironment remain poorly understood. Increasing evidence suggests that epigenetic events can modulate the crosstalk between neoplastic and non-neoplastic cells during tumor progression. In this review, we explore the current understanding of the involvement of epigenetic events in the modulation of the tumor microenvironment and its impact on head and neck cancer behavior. We also explore the latest therapeutic strategies that use epigenetic-modulating drugs to manage tumor growth and progression.



中文翻译:

头颈癌肿瘤微环境的表观遗传调控:挑战与机遇

由于对治疗的抵抗和导致高死亡率的攻击行为,头颈癌在全球范围内具有挑战性。最近的研究结果表明,肿瘤微环境在许多实体瘤(包括头颈癌)的维持和进展中发挥作用。参与调节和调节肿瘤微环境的机制仍然知之甚少。越来越多的证据表明,表观遗传事件可以调节肿瘤进展过程中肿瘤细胞和非肿瘤细胞之间的串扰。在这篇综述中,我们探讨了目前对表观遗传事件参与调节肿瘤微环境及其对头颈癌行为的影响的理解。

更新日期:2021-06-30
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