ABSTRACT Ivermectin® (IVM) is one of the most widely used antiparasitic drugs in human and veterinary medicine. This study assesses the effect of IVM on biometric characteristics and organ biomarkers of African catfish, Clarias gariepinus. Fish were exposed to 0.007, 0.013 and 0.033 mg/L of IVM and the brain, gill and liver were sampled on days 1, 7, 14, 21 and after 7 – day recovery. A mixed trend was observed in the values of condition factor and hepatosomatic index. There was concentration- and duration-dependent significant increase in the activities of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase in the tissues. While lipid peroxidation in the brain, liver and gill of the fish increased, activities of catalase, superoxide dismutase and glutathione peroxidase declined. IVM induced biochemical, oxidative stress, and biometric alterations in C. gariepinus juveniles. Thus, the use of the drug in aquaculture for the control of fish parasites requires stringent precautions.

中文翻译：

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伊维菌素®对非洲鲶鱼 Clarias gariepinus 生物特征和器官生物标志物的影响

摘要 伊维菌素® (IVM) 是人类和兽医学中使用最广泛的抗寄生虫药物之一。本研究评估了 IVM 对非洲鲶鱼 Clarias gariepinus 的生物特征和器官生物标志物的影响。鱼暴露于 0.007、0.013 和 0.033 毫克/升的 IVM，并在第 1、7、14、21 天和 7 天恢复后对大脑、鳃和肝脏进行取样。条件因子值和肝体指数值呈混合趋势。组织中丙氨酸转氨酶、天冬氨酸转氨酶和碱性磷酸酶的活性呈浓度和持续时间依赖性显着增加。鱼脑、肝脏和鳃中脂质过氧化增加，过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶活性下降。IVM 诱导的生化、氧化应激、和 C. gariepinus 幼鱼的生物特征改变。因此，在水产养殖中使用该药物控制鱼类寄生虫需要严格的预防措施。