Background

This study aimed to determine the prevalence of neuropathic pain (NeP) and fibromyalgia syndrome (FMS) in prediabetics and to compare them with normoglycemic controls, to disclose the impact of NeP and FMS in disease burden.

Methods

People, 18–65 years old, who were admitted to a tertiary hospital’s internal medicine outpatient clinic for routine health check-ups and then those who were newly diagnosed with prediabetes were recruited as a prediabetic group and those who were normoglycemic were recruited as a control group. Participants’ demographics and clinical data were recorded. The ShortForm-36 and Hospital Anxiety-Depression Scale were answered by the participants. The 2016 ACR Fibromyalgia Diagnostic Criteria and the painDETECT questionnaire were used for evaluation of FMS and NeP, respectively. One hundred nine prediabetics and 53 controls were enrolled.

Results

Eighty-four (77.1%) of 109 prediabetics and 37 of 53 controls (69.8%) were female. The mean age of the prediabetics was 48.85 (SD = 9.8) and the controls was 47.37 (SD = 11.11). Age, gender, BMI, smoking status, occupational, marital, and educational status were similar between the groups. FMS was more common in prediabetics 32 (29.6%) of 109 than in normoglycemics 7 (13.2 %) of 53 (p = 0.022). Eight of the prediabetics (7.4%) and 2 of the normoglycemics (3.8%) had possible or likely NeP (p = 0.273). The frequency of possible or likely NeP was higher in prediabetics with FMS than without FMS (p = 0.001). The prevalence of FMS was higher in prediabetics with NeP (87.5%) than without NeP (25.5%) (p = 0.001). Prediabetics with FMS or NeP had lower QoL than without FMS or NeP (p < 0.001, p = 0.014, respectively).

Conclusion

While evaluating prediabetics, it is important to assess both FMS and NeP.

中文翻译：

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两种嵌套综合征：糖尿病前期的纤维肌痛和神经性疼痛——一项初步研究

背景

本研究旨在确定糖尿病前期患者神经性疼痛 (NeP) 和纤维肌痛综合征 (FMS) 的患病率，并将其与血糖正常对照进行比较，以揭示 NeP 和 FMS 在疾病负担中的影响。

方法

年龄18～65岁，入三甲医院内科门诊进行常规健康检查，新诊断为糖尿病前期者为糖尿病前期组，血糖正常者为对照组团体。记录了参与者的人口统计学和临床​​数据。ShortForm-36 和医院焦虑抑郁量表由参与者回答。2016 ACR纤维肌痛诊断标准和painDETECT问卷分别用于评估FMS和NeP。招募了 109 名糖尿病前期患者和 53 名对照者。

结果

109 名糖尿病前期患者中的 84 名 (77.1%) 和 53 名对照组中的 37 名 (69.8%) 是女性。糖尿病前期患者的平均年龄为 48.85 (SD = 9.8)，对照组为 47.37 (SD = 11.11)。各组之间的年龄、性别、BMI、吸烟状况、职业、婚姻和教育状况相似。FMS 在 109 名糖尿病前期患者 32 (29.6%) 中比在 53 名血糖正常患者 7 (13.2%) 中更常见 ( p  = 0.022)。8 名前驱糖尿病患者 (7.4%) 和 2 名血糖正常者 (3.8%) 可能或可能有 NeP ( p  = 0.273)。有 FMS 的前驱糖尿病患者可能或可能出现 NeP 的频率高于没有 FMS 的糖尿病患者 ( p  = 0.001)。有 NeP 的前驱糖尿病患者的 FMS 患病率 (87.5%) 高于没有 NeP 的糖尿病患者 (25.5%) ( p = 0.001）。患有 FMS 或 NeP 的糖尿病前期患者的 QoL 低于没有 FMS 或 NeP 的患者（分别为p  < 0.001，p  = 0.014）。

结论

在评估糖尿病前期，评估 FMS 和 NeP 很重要。