The association between air pollution and multiple sclerosis (MS) is not entirely clear. This meta-analysis was aimed at determining the correlation between particulate matter (PM)2.5, PM10, and MS incidence/relapse. The literature search was performed in EMBASE, Web of Science, PubMed, and the gray literature. Sixteen articles were retrieved, and ten articles were included and evaluated. Three measures of association were used for the meta-analysis: odds ratio (cross-sectional and case-control studies), incidence rate ratio, or hazard ratio (cohort studies). Meta-analysis of those 3 studies on PM2.5 indicated that exposure to PM2.5 was associated with MS relapse and incidence ([95% confidence interval; CI] 1.178 [1.102, 1.279]), p #x3e; 0.05. Also, assessment of risk ratio for all studies showed a correlation between PMs (PM10 and PM2.5) and MS incidence and relapse ([95% CI] 1.28, [1.13–1.43]) p #x3c; 0.05. Collectively, we found that PM exposure (PM10 and PM2.5) in MS patients associates with the occurrence and relapse of disease.
Neuroimmunomodulation

中文翻译：

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颗粒物暴露与多发性硬化症的关联：系统评价和荟萃分析

空气污染与多发性硬化症 (MS) 之间的关联并不完全清楚。该荟萃分析旨在确定颗粒物 (PM)2.5、PM10 和 MS 发病/复发之间的相关性。文献检索在 EMBASE、Web of Science、PubMed 和灰色文献中进行。检索到 16 篇文章，其中 10 篇文章被收录和评估。荟萃分析使用了三种关联度量：优势比（横断面和病例对照研究）、发生率比或风险比（队列研究）。对这 3 项 PM2.5 研究的荟萃分析表明，暴露于 PM2.5 与 MS 复发和发病率相关（[95% 置信区间；CI] 1.178 [1.102, 1.279]），p#x3e; 0.05。此外，所有研究的风险比评估显示 PM（PM10 和 PM2.5）与 MS 发病率和复发之间存在相关性（[95% CI] 1.28，[1.13–1.43]）p #x3c；0.05。总的来说，我们发现 MS 患者的 PM 暴露（PM10 和 PM2.5）与疾病的发生和复发有关。
神经免疫调节