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Survey of amyloidosis cases among different free-living wild and zoo animals
Amyloid ( IF 5.5 ) Pub Date : 2021-06-16 , DOI: 10.1080/13506129.2021.1940931
Hailey B Penticoff 1 , Hannah K Hipkiss 1 , Ashley A Hetak 1 , Dalen W Agnew 1 , Jessica S Fortin 1
Affiliation  

Abstract

Amyloidosis comprises a range of protein-folding disorders characterised by a buildup of amyloid deposits in one or multiple organs. The pathogenesis and pathologic findings of amyloidosis can vary widely due to the nature of the precursor protein. In veterinary medicine, there are 10 proteins known to form amyloid deposits in various organs. This review aims to compare amyloidosis cases among different free-living wild and zoo animals focussing in part on the determination of the species particularly susceptible to the amyloid formation and specific prone-to-aggregate protein commonly involved. This review addresses the transmission of AA amyloidosis pertinent to institutions, such as zoos, housing multiple individuals and species in relatively close proximity. In addition, this review includes summarisation for definitive diagnosis of single or multiple cases of amyloidosis affecting free-living wild and zoo animals. Insights into the diversity, transmission, and pathogenesis of known amyloidogenic proteins and species prevalently affected may help to establish a preventive intervention and stimulate the discovery of new diagnostic and therapeutic strategies.



中文翻译:

不同自由生活野生动物和动物园动物淀粉样变性病例调查

摘要

淀粉样变性包括一系列蛋白质折叠障碍,其特征是淀粉样蛋白沉积在一个或多个器官中。由于前体蛋白的性质,淀粉样变性的发病机制和病理学发现可能有很大差异。在兽医学中,已知有 10 种蛋白质会在各种器官中形成淀粉样蛋白沉积物。本综述旨在比较不同自由生活的野生动物和动物园动物之间的淀粉样变性病例,部分重点是确定对淀粉样蛋白形成特别敏感的物种和通常涉及的特定易聚集蛋白。这篇综述讨论了与机构相关的 AA 淀粉样变性病的传播,例如动物园,在相对较近的地方安置多个个体和物种。此外,这篇综述包括对影响自由生活的野生动物和动物园动物的单个或多个淀粉样变性病例的明确诊断的总结。深入了解已知的淀粉样蛋白和普遍受影响的物种的多样性、传播和发病机制可能有助于建立预防性干预措施并促进新诊断和治疗策略的发现。

更新日期:2021-08-09
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