Proton pump inhibitors (PPIs) are among the most commonly used medications in the world; however, these drugs carry the risk of patient harm, including acute and chronic kidney disease, Clostridium difficile infection, hypomagnesemia, and fractures. In the hospital setting, PPIs are overused for stress ulcer prophylaxis and gastrointestinal bleeding, and PPI use often continues after discharge. Numerous multifaceted interventions have demonstrated safe and effective reduction of PPI use in the inpatient setting. This narrative review and the resulting implementation guide summarize published interventions to reduce inappropriate PPI use and provide a strategy for quality improvement teams.

质子泵抑制剂 (PPI) 是世界上最常用的药物之一。然而，这些药物存在对患者造成伤害的风险，包括急性和慢性肾病、艰难梭菌感染、低镁血症和骨折。在医院环境中，PPI 被过度用于预防应激性溃疡和胃肠道出血，并且在出院后经常继续使用 PPI。许多多方面的干预措施已证明可以安全有效地减少住院环境中 PPI 的使用。该叙述性审查和由此产生的实施指南总结了已发布的干预措施，以减少不适当的 PPI 使用，并为质量改进团队提供策略。