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Secondary metabolites from Hypericum trichocaulon Boiss. & Heldr., growing wild in the island of crete
Biochemical Systematics and Ecology ( IF 1.6 ) Pub Date : 2021-06-16 , DOI: 10.1016/j.bse.2021.104294
Artemis Daskalaki , Maria-Eleni Grafakou , Christina Barda , Zacharias Kypriotakis , Jörg Heilmann , Helen Skaltsa

Eleven compounds were isolated from the aerial blooming parts of Hypericum trichocaulon Boiss. & Heldr., a narrow endemic plant of the island of Crete (Greece). These compounds comprise one previously undescribed prenylated phloroglycinol derivative (adhyperfoliatin), together with ten known compounds, procyanidin A2, hyperixanthone A, (E)-chlorogenic acid, trans-phytol, five flavonoids, i.e. I3,II8-biapigenin, quercitrin, hyperoside, rutin, myricitrin and one fatty acid. The structures of the isolated compounds were established by means of 1D and 2D NMR, as well as MS spectral analyses. Phloroglucinol derivatives are recognized as chemophenetic markers for the genus Hypericum, and the isolation of adhyperfoliatin contributes to the characterization of the section Drosocarpium Spach, where the under-investigation taxon belongs. Moreover, the investigation of the methanol extract led to the isolation of myricitrin in high amounts, a specialized metabolite which also serves as a marker for this section.



中文翻译:

来自金丝桃属植物的次生代谢物。& Heldr.,在克里特岛野地生长

Hypericum trichocaulon Boiss的气生开花部分中分离出11 种化合物。& Heldr.,一种狭长的克里特岛(希腊)特有植物。这些化合物包含一种以前未描述的异戊二烯化间苯三酚衍生物(adhyperfoliatin),以及十种已知化合物,原花青素 A 2、超黄嘌呤酮 A、(E)-绿原酸、反式-植醇、五种黄酮类化合物,即 I3,II8-biapigenin、槲皮素、金丝桃苷、芦丁、杨梅苷和一种脂肪酸。通过一维和二维核磁共振以及质谱分析确定了分离化合物的结构。间苯三酚衍生物被认为是金丝桃属的化学表型标志物Adhyperfoliatin 的分离有助于确定 Drosocarpium Spach 部分的特征,该部分属于正在研究的分类群。此外,对甲醇提取物的研究导致分离出大量杨梅苷,这是一种特殊的代谢物,也可作为本部分的标记物。

更新日期:2021-06-17
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