Probiotics and Antimicrobial Proteins ( IF 4.9 ) Pub Date : 2021-06-16 , DOI: 10.1007/s12602-021-09779-3 Astghik Z Pepoyan 1, 2, 3 , Elya S Pepoyan 1, 4 , Lilit Galstyan 4 , Natalya A Harutyunyan 1 , Vardan V Tsaturyan 2, 4 , Tamas Torok 5 , Alexey M Ermakov 6 , Igor V Popov 6 , Richard Weeks 7 , Michael L Chikindas 6, 7, 8
Possible mechanisms involved in sex-dependent differences in the gut microbiota have a growing interest worldwide, but the effects of probiotics dependence on the gender of the host have remained outside of researchers’ attention until now. Previously, our research data described gender-specific differences in the gut microbiota of Armenian Familial Mediterranean fever (FMF) patients. Taking into account the possible association of Prevotella spp. with depressive disorders, the aim of the current investigations was an evaluation of changes in the abundance of gut Prevotella of FMF patients in association with the patient’s depression and gender. The differences between healthy and FMF diseased gut microbiota in terms of Prevotella abundance were revealed. In addition, the gender-dependent effects of immunobiotic/psychobiotic Narine on the abundance of gut Prevotella of FMF patients and patients’ depression scores were shown by us in this study.
中文翻译:
免疫生物/精神生物嗜酸乳杆菌菌株 INMIA 9602 Er 317/402 Narine 对家族性地中海热中肠道普雷沃氏菌的影响:性别相关影响
涉及肠道微生物群性别依赖性差异的可能机制在全世界范围内引起了越来越多的兴趣,但直到现在,益生菌对宿主性别的依赖性仍然没有引起研究人员的注意。此前,我们的研究数据描述了亚美尼亚家族性地中海热 (FMF) 患者肠道微生物群的性别差异。考虑到Prevotella spp的可能关联。对于抑郁症,目前调查的目的是评估FMF 患者肠道Prevotella丰度与患者抑郁症和性别相关的变化。就普氏菌而言,健康和 FMF 患病肠道菌群之间的差异 丰度显露。此外,我们在本研究中展示了免疫生物/精神生物 Narine 对FMF 患者肠道普氏菌丰度和患者抑郁评分的性别依赖性影响。