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Revisiting the Notion of Deleterious Sweeps.
GENETICS ( IF 3.3 ) Pub Date : 2021-06-14 , DOI: 10.1093/genetics/iyab094
Parul Johri 1 , Brian Charlesworth 2 , Emma K Howell 1 , Michael Lynch 1, 3 , Jeffrey D Jensen 1
Affiliation  

It has previously been shown that, conditional on its fixation, the time to fixation of a semi-dominant deleterious autosomal mutation in a randomly mating population is the same as that of an advantageous mutation. This result implies that deleterious mutations could generate selective sweep-like effects. Although their fixation probabilities greatly differ, the much larger input of deleterious relative to beneficial mutations suggests that this phenomenon could be important. We here examine how the fixation of mildly deleterious mutations affects levels and patterns of polymorphism at linked sites - both in the presence and absence of interference amongst deleterious mutations - and how this class of sites may contribute to divergence between-populations and species. We find that, while deleterious fixations are unlikely to represent a significant proportion of outliers in polymorphism-based genomic scans within populations, minor shifts in the frequencies of deleterious mutations can influence the proportions of private variants and the value of FST after a recent population split. As sites subject to deleterious mutations are necessarily found in functional genomic regions, interpretations in terms of recurrent positive selection may require reconsideration.

中文翻译:

重新审视有害扫描的概念。

先前已经表明,在其固定的条件下,随机交配群体中半显性有害常染色体突变的固定时间与有利突变的固定时间相同。这一结果意味着有害突变可能会产生选择性的扫掠效应。尽管它们的固定概率有很大差异,但有害突变相对于有益突变的输入要大得多,这表明这种现象可能很重要。我们在这里检查轻度有害突变的固定如何影响链接位点的多态性水平和模式 - 无论是否存在有害突变之间的干扰 - 以及此类位点如何导致种群和物种之间的差异。我们发现,虽然有害固定不太可能代表种群内基于多态性的基因组扫描中很大比例的异常值,但有害突变频率的微小变化会影响私有变异的比例和最近种群分裂后的 FST 值。由于在功能基因组区域中必然会发现受有害突变影响的位点,因此可能需要重新考虑对反复阳性选择的解释。
更新日期:2021-06-17
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