Reactive chromatography is beneficial for a reaction where reaction equilibrium limits productivity, the product forms azeotropes with the reactants, and product separation is difficult due to nonideality in the phase equilibrium. 2,2 Di-methoxy propane (DMP) production from methanol and acetone is one such example where DMP equilibrium conversion is less than 15% at 15 °C reaction temperature in a conventional batch process. Furthermore, DMP forms azeotropes with acetone and methanol, and product separation is difficult due to nonideality in the phase equilibrium. In this work, synthesis of DMP from methanol and acetone using an acidic resin (Amberlyst-15) as an adsorbent/catalyst is investigated in a fixed-bed chromatographic reactor (FBCR). Addition of solvents such as hexane or cyclohexane into the reaction system in the FBCR favorably influences the affinity of acetone and DMP to the catalyst bed. The addition of equal molar amounts of hexane and acetone results in an increase in the affinity of acetone toward the resin and a decrease in the affinity of DMP toward the resin. Thus, with the aid of solvents, one can completely exhaust the acetone in the reaction regime and thus decrease the downstream processing cost drastically. Moreover, DMP yield increases threefold compared to the case when a solvent is not used. The parameters in the reaction kinetics, dispersion coefficient, and adsorption parameter were estimated by conducting independent experiments in the FBCR. The reaction kinetics and adsorption isotherm results are obtained from the FBCR implemented in the model, which predicts the results that are in good agreement with the experimental data.

中文翻译：

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溶剂辅助反应色谱法合成 2,2 二甲氧基丙烷的可行性

反应性色谱有利于反应平衡限制生产率的反应，产物与反应物形成共沸物，并且由于相平衡的非理想性而难以分离产物。从甲醇和丙酮生产 2,2 二甲氧基丙烷 (DMP) 就是一个这样的例子，其中 DMP 平衡转化率在 15 °C 反应温度下在传统的间歇过程中低于 15%。此外，DMP 与丙酮和甲醇形成共沸物，由于相平衡不理想，产品分离很困难。在这项工作中，在固定床色谱反应器 (FBCR) 中研究了使用酸性树脂 (Amberlyst-15) 作为吸附剂/催化剂从甲醇和丙酮合成 DMP。在 FBCR 的反应体系中加入溶剂如己烷或环己烷有利于影响丙酮和 DMP 对催化剂床的亲和力。添加等摩尔量的己烷和丙酮导致丙酮对树脂的亲和力增加，而 DMP 对树脂的亲和力降低。因此，在溶剂的帮助下，人们可以完全耗尽反应体系中的丙酮，从而大大降低下游加工成本。此外，与不使用溶剂的情况相比，DMP 产量增加了三倍。反应动力学参数、分散系数和吸附参数是通过在 FBCR 中进行独立实验来估计的。反应动力学和吸附等温线结果是从模型中实施的 FBCR 中获得的，