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E2-CD154 vaccine candidate is safe and immunogenic in pregnant sows, and the maternal derived neutralizing antibodies protect piglets from classical swine fever virus challenge
Veterinary Microbiology ( IF 3.3 ) Pub Date : 2021-06-16 , DOI: 10.1016/j.vetmic.2021.109153
Danny Pérez-Pérez 1 , Yusmel Sordo-Puga 1 , María Pilar Rodríguez-Moltó 1 , Talía Sardina 1 , Elaine Santana 1 , Carlos Montero 1 , Julio Ancizar 2 , Yaneris Cabrera 2 , Ángela Tuero 3 , Paula Naranjo 4 , Iliana Sosa-Testé 5 , Fé Fernandez 5 , Rodolfo Valdés 6 , Carlos A Duarte 1 , Marisela Suárez-Pedroso 1
Affiliation  

E2-CD154 subunit vaccine candidate is safe and protects swine from Classical Swine Fever (CSF). However, its safety and immunogenicity in pregnant sows, and the capacity of maternal derived neutralizing antibodies (MDNA) to protect the offspring is yet to be demonstrated. The aim of this study was to evaluate the safety and immunogenicity of E2-CD154 in pregnant sows, and the capacity of MDNA to protect the offspring. Seventeen pregnant sows were vaccinated twice with E2-CD154 in either the first or the second third of pregnancy. Pregnancy and litter parameters were compared with a control group of non-vaccinated sows. Neutralizing antibodies (NAb) were monitored. The time course of MDNA was assessed in a group of six piglets born to an E2-CD154 immunized sow, and the animals were challenged with CSFV at day 63 after birth. No local or systemic adverse effects were found. Neither abortions, nor congenital malformations, nor stillbirths were observed. All sows develop high NAb titers after the first immunization. Piglets born to an E2-CD154 vaccinated sow still showed MDNA titers of 1:100 at day 63 after birth. Five animals were negative for virus isolation after challenge, and showed neither signs of CSF, nor macroscopic lesions in the organs. The other piglet was positive for CSFV isolation, and macroscopic lesions were observed in the spleen, although no clinical signs of CSF other than fever were detected. E2-CD154 vaccine candidate was safe and immunogenic in pregnant sows, and the passive immunity transmitted to the offspring was still protective by day 63 after birth.



中文翻译:

E2-CD154 候选疫苗在怀孕母猪中是安全且具有免疫原性的,母源中和抗体可保护仔猪免受猪瘟病毒攻击

E2-CD154 亚单位候选疫苗是安全的,可保护猪免受猪瘟 (CSF) 的侵害。然而,其在怀孕母猪中的安全性和免疫原性,以及母源中和抗体 (MDNA) 保护后代的能力还有待证明。本研究的目的是评估 E2-CD154 在怀孕母猪中的安全性和免疫原性,以及 MDNA 保护后代的能力。17 头怀孕母猪在怀孕的前三分之一或后三分之一接种了两次 E2-CD154。将妊娠和产仔参数与对照组的未接种疫苗的母猪进行比较。监测中和抗体(NAb)。在 E2-CD154 免疫母猪所生的一组 6 头小猪中评估 MDNA 的时间进程,并在出生后第 63 天用 CSFV 攻击动物。未发现局部或全身不良反应。没有观察到流产、先天性畸形和死产。所有母猪在第一次免疫后都会产生高 NAb 滴度。接种 E2-CD154 的母猪所生的仔猪在出生后第 63 天仍显示 1:100 的 MDNA 滴度。五只动物在攻击后病毒分离呈阴性,既没有出现脑脊液的迹象,也没有出现肉眼可见的器官损伤。另一头仔猪的 CSFV 分离呈阳性,在脾脏中观察到肉眼可见的病变,但除发热外未检测到 CSF 的临床症状。E2-CD154 候选疫苗在怀孕母猪中是安全且具有免疫原性的,并且传递给后代的被动免疫在出生后第 63 天仍然具有保护性。也没有观察到死产。所有母猪在第一次免疫后都会产生高 NAb 滴度。接种 E2-CD154 的母猪所生的仔猪在出生后第 63 天仍显示 1:100 的 MDNA 滴度。五只动物在攻击后病毒分离呈阴性,既没有出现脑脊液的迹象,也没有出现肉眼可见的器官损伤。另一头仔猪的 CSFV 分离呈阳性,在脾脏中观察到肉眼可见的病变,但除发热外未检测到 CSF 的临床症状。E2-CD154 候选疫苗在怀孕母猪中是安全且具有免疫原性的,并且传递给后代的被动免疫在出生后第 63 天仍然具有保护性。也没有观察到死产。所有母猪在第一次免疫后都会产生高 NAb 滴度。接种 E2-CD154 的母猪所生的仔猪在出生后第 63 天仍显示 1:100 的 MDNA 滴度。五只动物在攻击后病毒分离呈阴性,既没有出现脑脊液的迹象,也没有出现肉眼可见的器官损伤。另一头仔猪的 CSFV 分离呈阳性,在脾脏中观察到肉眼可见的病变,但除发热外未检测到 CSF 的临床症状。E2-CD154 候选疫苗在怀孕母猪中是安全且具有免疫原性的,并且传递给后代的被动免疫在出生后第 63 天仍然具有保护性。五只动物在攻击后病毒分离呈阴性,既没有出现脑脊液的迹象,也没有出现肉眼可见的器官损伤。另一头仔猪的 CSFV 分离呈阳性,在脾脏中观察到肉眼可见的病变,但除发热外未检测到 CSF 的临床症状。E2-CD154 候选疫苗在怀孕母猪中是安全且具有免疫原性的,并且传递给后代的被动免疫在出生后第 63 天仍然具有保护性。五只动物在攻击后病毒分离呈阴性,既没有出现脑脊液的迹象,也没有出现肉眼可见的器官损伤。另一头仔猪的 CSFV 分离呈阳性,在脾脏中观察到肉眼可见的病变,但除发热外未检测到 CSF 的临床症状。E2-CD154 候选疫苗在怀孕母猪中是安全且具有免疫原性的,并且传递给后代的被动免疫在出生后第 63 天仍然具有保护性。

更新日期:2021-07-13
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