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Acupuncture for Parkinson’s Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit
Neural Plasticity ( IF 3.1 ) Pub Date : 2021-06-16 , DOI: 10.1155/2021/9926445
Yadan Zhao 1 , Zichen Zhang 1 , Siru Qin 1 , Wen Fan 2 , Wei Li 1 , Jingyi Liu 1 , Songtao Wang 1 , Zhifang Xu 1, 3 , Meidan Zhao 1, 3
Affiliation  

Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disease caused by degeneration of dopaminergic neurons in the substantia nigra. Existing pharmaceutical treatments offer alleviation of symptoms but cannot delay disease progression and are often associated with significant side effects. Clinical studies have demonstrated that acupuncture may be beneficial for PD treatment, particularly in terms of ameliorating PD symptoms when combined with anti-PD medication, reducing the required dose of medication and associated side effects. During early stages of PD, acupuncture may even be used to replace medication. It has also been found that acupuncture can protect dopaminergic neurons from degeneration via antioxidative stress, anti-inflammatory, and antiapoptotic pathways as well as modulating the neurotransmitter balance in the basal ganglia circuit. Here, we review current studies and reflect on the potential of acupuncture as a novel and effective treatment strategy for PD. We found that particularly during the early stages, acupuncture may reduce neurodegeneration of dopaminergic neurons and regulate the balance of the dopaminergic circuit, thus delaying the progression of the disease. The benefits of acupuncture will need to be further verified through basic and clinical studies.

中文翻译:

针灸治疗帕金森病:多巴胺能神经回路的疗效评估和机制

帕金森病(PD)是一种由黑质多巴胺能神经元退化引起的慢性进行性神经退行性疾病。现有的药物治疗可以缓解症状,但不能延缓疾病进展,并且通常与显着的副作用有关。临床研究表明,针灸可能对 PD 治疗有益,特别是在与抗 PD 药物联合使用时可改善 PD 症状、减少所需的药物剂量和相关副作用。在 PD 的早期阶段,针灸甚至可以用来代替药物。还发现针灸可以通过抗氧化应激、抗炎、和抗凋亡途径以及调节基底神经节回路中的神经递质平衡。在这里,我们回顾了当前的研究,并反思了针灸作为一种新的有效治疗 PD 策略的潜力。我们发现,特别是在早期,针灸可以减少多巴胺能神经元的神经变性,调节多巴胺能回路的平衡,从而延缓疾病的进展。针灸的益处将需要通过基础和临床研究进一步验证。针灸可以减少多巴胺能神经元的神经变性,调节多巴胺能回路的平衡,从而延缓疾病的进展。针灸的益处将需要通过基础和临床研究进一步验证。针灸可以减少多巴胺能神经元的神经变性,调节多巴胺能回路的平衡,从而延缓疾病的进展。针灸的益处将需要通过基础和临床研究进一步验证。
更新日期:2021-06-16
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