Objectives

Inflammatory joint disease (IJD) is associated with an increased risk of developing cardiovascular disease (CVD). Arterial stiffness is both a risk factor and a surrogate marker for CVD. This study aims to compare arterial stiffness across patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis, and, by extension, to explore the relationship between arterial stiffness and the estimated CVD risk by the Systematic COronary Risk Evaluation (SCORE) algorithm.

Method

During the study period, from April 2017 to June 2018, 196 patients with IJD visited the Preventive Cardio-Rheuma Clinic in Oslo, Norway. A CVD risk stratification was performed, including the assessment of traditional risk factors and the measurement of arterial stiffness.

Results

Thirty-six patients (18.4%) had elevated aortic pulse wave velocity (aPWV) (≥ 10 m/s). After adjustment for age and heart rate, arterial stiffness was comparable across the IJD entities (p = 0.69). Associated factors, revealed by regression analysis, were age, blood pressure, heart rate, presence of carotid plaques, establis hed CVD, non-steroidal anti-inflammatory drugs, and statin use. Furthermore, aPWV was positively correlated with estimated CVD risk (r = 0.7, p < 0.001) and patients with a very high predicted CVD risk (SCORE ≥ 10%) had significantly higher aPWV than patients at lower CVD risk (9.2 vs 7.5 m/s, p < 0.001).

Conclusion

The degree of arterial stiffness was comparable across the IJD entities and was highly associated with the estimated CVD risk. Our findings support the need for an increased focus on prevention of CVD in all patients with IJD.

中文翻译：

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炎症性关节病实体的动脉僵硬度程度相当

目标

炎症性关节病 (IJD) 与患心血管疾病 (CVD) 的风险增加有关。动脉僵硬度既是 CVD 的危险因素，也是替代标志物。本研究旨在比较类风湿性关节炎、强直性脊柱炎和银屑病关节炎患者的动脉僵硬度，并通过系统冠状动脉风险评估 (SCORE) 算法探索动脉僵硬度与估计的 CVD 风险之间的关系。

方法

在研究期间，从 2017 年 4 月到 2018 年 6 月，196 名 IJD 患者访问了位于挪威奥斯陆的预防性心风湿病诊所。进行了 CVD 风险分层，包括评估传统风险因素和测量动脉硬度。

结果

36 名患者 (18.4%) 的主动脉脉搏波速度 (aPWV) (≥ 10 m/s) 升高。调整年龄和心率后，IJD 患者的动脉僵硬度相当（p = 0.69）。回归分析揭示的相关因素是年龄、血压、心率、颈动脉斑块的存在、已患心血管疾病、非甾体抗炎药和他汀类药物的使用。此外，aPWV 与估计的 CVD 风险呈正相关（r = 0.7，p < 0.001），具有极高预测 CVD 风险（SCORE ≥ 10%）的患者的 aPWV 显着高于 CVD 风险较低的患者（9.2 vs 7.5 m/ s, p < 0.001)。

结论

动脉僵硬程度在 IJD 实体中具有可比性，并且与估计的 CVD 风险高度相关。我们的研究结果支持需要更加关注所有 IJD 患者的 CVD 预防。