ABSTRACT A network model of striatum that comprises medium spiny neurons (MSNs) and fast spiking interneurons (FSIs) is constructed following the work of Humphries et al. (2009). The dynamic behavior of striatum microcircuit is investigated using a dopamine-modulated modified Izhikevich neuron model. The influences of dopamine on the synchronization behavior of the striatal microcircuit and the dependence on receptor type are investigated with and without time delay. To investigate the role of two types of dopamine receptors, D1 and D2, on the overall activity of the striatum microcircuit, the activities of two groups are considered as disconnected and connected. When the connection exists between D1 and D2 sub-networks with zero dopamine and time delay, neuronal activity decreases because of an inhibitory effect of the connected neurons of the other sub-network. In the presence of dopamine, an increase in the activity of D1 type MSNs and quiescent behavior of D2 type MSNs are observed when the time delay is zero. However, the diversity in synchronization of D1 and D2 type MSNs is observed for different synaptic time delays and synaptic strengths in the case that dopamine is present.

中文翻译：

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多巴胺对纹状体同步行为的建模影响

摘要 根据 Humphries 等人的工作，构建了包含中等棘状神经元 (MSN) 和快速棘状中间神经元 (FSI) 的纹状体网络模型。(2009)。使用多巴胺调制的改良 Izhikevich 神经元模型研究纹状体微电路的动态行为。研究了多巴胺对纹状体微电路同步行为的影响以及对受体类型的依赖性，有无时间延迟。为了研究两种类型的多巴胺受体 D1 和 D2 对纹状体微电路整体活动的作用，将两组的活动视为断开和连接。当 D1 和 D2 子网之间存在零多巴胺和时延的连接时，由于其他子网络的连接神经元的抑制作用，神经元活动减少。在多巴胺存在的情况下，当时间延迟为零时，观察到 D1 型 MSN 的活性增加和 D2 型 MSN 的静止行为。然而，在存在多巴胺的情况下，对于不同的突触时间延迟和突触强度，观察到 D1 和 D2 型 MSN 同步的多样性。