Clusia criuva belongs to the Clusiaceae family and it is endemic to the rupestrian fields in Chapada Diamantina National Park (Brazil). Phytochemical investigation of C. criuva trunks led to the isolation of five triterpenoids [winchic acid (1), betulinic acid (2), lupeol (3), friedelin (4), and friedelinol (5)], four steroids [lanosterol (6), stigmasterol (7), β-sitosterol (8), and sitostenone (9)], seven polyprenylated benzophenone derivatives [propolone A (10), propolone B (11), propolone C (12), propolone D (13), sampsonione B (14), hyperisampsin E (15), and hyperisampsin F (16)], four xanthones [neriifolone C (17), 6-deoxyisojacareubin (18), osajaxanthone F (19), and brasilixanthone B (20)], two biphenyls [aucuparina (21) and 2,2-dimethyl-5-hydroxy-7-phenylchromene (22)], and two tocotrienol derivatives [2Z- and 2E-δ-tocotrienoloic acids (23 and 24)]. Compounds 1, 11, 12, 15, and 16 were isolated for the first time in the Clusiaceae family, compounds 17, 19 and 21 were isolated for the first time in the genus Clusia, whereas 2–10, 13, 14, 18, 20, 22–24 were isolated for the first time in Clusia criuva. Compounds 1, 2, 11, 12, 13 and 15 showed potent in vitro cytotoxic activity against GL-15 glioblastoma-derived human cell line. Chemophenetics significance of these compounds is described herein.

Clusia criuva属于 Clusiaceae 科，它是 Chapada Diamantina 国家公园（巴西）的 rupestrian 田地中的特有种。C. criuva树干的植物化学研究导致分离出五种三萜类化合物 [绞盘酸 ( 1 )、桦木酸 ( 2 )、羽扇豆醇 ( 3 )、弗里德林 ( 4 ) 和弗里德林醇 ( 5 )]、四种类固醇 [羊毛甾醇 ( 6) )、豆甾醇 ( 7 )、β-谷甾醇 ( 8 ) 和谷甾烯酮 ( 9 )]、七种聚异戊二烯化二苯甲酮衍生物 [propolone A ( 10 )、propolone B ( 11 )、propolone C ( 12)），propolone d（13），sampsonione B（14），hyperisampsin E（15），和hyperisampsin F（16）]，四个氧杂蒽酮[neriifolone C（17），6- deoxyisojacareubin（18），osajaxanthone F（19），和巴西杂蒽酮 B ( 20 )]、两种联苯 [aucuparina ( 21 ) 和 2,2-二甲基-5-羟基-7-苯基色烯 ( 22 )] 和两种生育三烯酚衍生物 [2 Z - 和 2 E -δ-生育三烯酚酸( 23和24 )]。化合物1，11，12，15和16中分离得到的藤黄科家族的第一次，化合物17，19和21中分离得到属中的第一次Clusia，而2 - 10，13，14，18，20，22 - 24中分离得到第一次在Clusia criuva。化合物1 , 2 , 11 , 12 , 13和15在体外显示有效对 GL-15 胶质母细胞瘤衍生的人细胞系的细胞毒活性。本文描述了这些化合物的化学表观意义。