Allergen extract- and component-based diagnostics in children of the ALLIANCE asthma cohort,Clinical & Experimental Allergy

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Allergen extract- and component-based diagnostics in children of the ALLIANCE asthma cohort
Clinical & Experimental Allergy ( IF 6.1 ) Pub Date : 2021-06-15 , DOI: 10.1111/cea.13964
Chrysanthi Skevaki ₁ , Pavel Tafo ₁ , Kathrin Eiringhaus ₁ , Nina Timmesfeld ₂ , Markus Weckmann _{3,

4} , Christine Happle ₅ , Philipp P Nelson ₁ , Nicole Maison _{6,

7,

8} , Bianca Schaub _{6,

8} , Isabell Ricklefs _{3,

4} , Oliver Fuchs _{3,

4,

6} , Erika von Mutius _{6,

7,

8} , Matthias Volkmar Kopp _{3,

4,

9} , Harald Renz ₁ , Gesine Hansen ₅ , Anna-Maria Dittrich ₅ ,

Affiliation

Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Philipps University Marburg, Marburg, Germany.
Department of Medical Informatics, Biometry and Epidemiology, Ruhr University, Bochum, Germany.
Department of Pediatric Pneumology & Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany.
Member of the German Center of Lung Research (DZL), Airway Research Center North (ARCN), Germany.
Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, BREATH German Center for Lung Research (DZL), Hannover, Germany.
Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany.
Institute of Asthma and Allergy Prevention, Helmholtz Centre, Munich, Germany.
German Centre for Lung Research, Munich, Germany.
Division of Respiratory Medicine, Department of Pediatrics, University Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.

Current in vitro allergen-specific IgE (sIgE) detection assays measure IgE against allergen extracts or molecules in a single- or multiplex approach. Direct comparisons of the performance of such assays among young children with common presentations of allergic diseases regardless of sensitization status are largely missing.

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