Purpose

To evaluate the association between serum 25-hydroxy vitamin D level and arterial stiffness in type 2 diabetes patients with intermediate chronic kidney disease (CKD).

Methods

The serum 25-hydroxy vitamin D level and various parameters of vascular functions were assessed in type 2 diabetes patients with intermediate CKD (stages 3a and 3b). The carotid-femoral pulse wave velocity (cfPWV) among vitamin D-deficient, -insufficient, and normal patients was compared.

Results

One hundred and twenty-one patients were included. The cfPWV in the vitamin D-deficient group (1190.32 ± 256.95 cm/s) was significantly higher (p < 0.05) than that in the vitamin D-insufficient (1053.74 ± 138.96 cm/s) and normal (1038.45 ± 171.08 cm/s) groups. Similarly, the aortic augmentation pressure (13.29 ± 5.18 mm Hg) in the vitamin D-deficient group was significantly higher (p < 0.05) than that in the vitamin D-insufficient (10.01 ± 5.12 mm Hg) and normal groups (9.27 ± 4.97 mm Hg). Furthermore, the augmentation index was 24.66 ± 8.84% in the vitamin D-deficient (p < 0.05) as compared to 20.11 ± 8.12% in the vitamin D-insufficient group and 20.36 ± 6.14% in the normal group. Other vascular parameters were not significantly different among the groups.

Conclusion

Different parameters of arterial stiffness, such as cfPWV, aortic augmentation pressure, and augmentation index, were significantly higher in the vitamin D-deficient group as compared to those in the vitamin D-insufficient and normal groups among type 2 diabetes patients with intermediate CKD.

中文翻译：

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维生素 D 对 2 型糖尿病合并中度慢性肾病患者动脉僵硬度的影响

目的

评估血清 25-羟基维生素 D 水平与患有中度慢性肾病 (CKD) 的 2 型糖尿病患者的动脉僵硬度之间的关联。

方法

在患有中度 CKD 的 2 型糖尿病患者（3a 和 3b 期）中评估了血清 25-羟基维生素 D 水平和血管功能的各种参数。比较了维生素 D 缺乏、维生素 D 不足和正常患者的颈股动脉脉搏波速度 (cfPWV)。

结果

包括 121 名患者。维生素 D 缺乏组 (1190.32 ± 256.95 cm/s) 的 cfPWV 显着高于 ( p  < 0.05) 维生素 D 不足组 (1053.74 ± 138.96 cm/s) 和正常组 (1038.45 ± 171.08 cm/s) ) 组。同样，维生素 D 缺乏组的主动脉扩张压力 (13.29 ± 5.18 mm Hg) 显着高于 ( p  < 0.05) 维生素 D 不足组 (10.01 ± 5.12 mm Hg) 和正常组 (9.27 ± 4.97)毫米汞柱）。此外，维生素 D 缺乏组的增强指数为 24.66 ± 8.84% ( p  < 0.05)，而维生素 D 不足组为 20.11 ± 8.12%，正常组为 20.36 ± 6.14%。其他血管参数在各组之间没有显着差异。

结论

与维生素 D 不足组和正常组相比，维生素 D 缺乏组的不同动脉僵硬度参数，如 cfPWV、主动脉增加压力和增加指数，在中度 CKD 的 2 型糖尿病患者中显着升高。