Parkinson’s disease (PD) is the second most common neurodegenerative disease, which manifests with both motor and non-motor symptoms. Circadian rhythm dysregulation, as one of the most challenging non-motor features of PD, usually appears long before obvious motor symptoms. Moreover, the dysregulated circadian rhythm has recently been reported to play pivotal roles in PD pathogenesis, and it has emerged as a hot topic in PD research. In this review, we briefly introduce the circadian rhythm and circadian rhythm-related genes, and then summarize recent research progress on the altered circadian rhythm in PD, ranging from clinical features to the possible causes of PD-related circadian disorders. We believe that future comprehensive studies on the topic may not only help us to explore the mechanisms of PD, but also shed light on the better management of PD.

帕金森病 (PD) 是第二常见的神经退行性疾病，它同时表现出运动和非运动症状。昼夜节律失调作为 PD 最具挑战性的非运动特征之一，通常在明显运动症状之前很久就出现。此外，最近有报道称，失调的昼夜节律在 PD 发病机制中起关键作用，并已成为 PD 研究的热门话题。在这篇综述中，我们简要介绍了昼夜节律和昼夜节律相关基因，然后总结了近期关于 PD 昼夜节律改变的研究进展，从临床特征到 PD 相关昼夜节律紊乱的可能原因。我们相信，未来对该主题的全面研究不仅可以帮助我们探索 PD 的机制，