Considering the urgency of the ongoing COVID-19 pandemic, detection of various new mutant strains and future potential re-emergence of novel coronaviruses, repurposing of approved drugs such as Ivermectin could be worthy of attention. This evidence-based review article aims to discuss the mechanism of action of ivermectin against SARS-CoV-2 and summarizing the available literature over the years. A schematic of the key cellular and biomolecular interactions between Ivermectin, host cell, and SARS-CoV-2 in COVID-19 pathogenesis and prevention of complications have been proposed.

中文翻译：

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伊维菌素对 SARS-CoV-2 的作用机制：一篇循证临床综述文章

考虑到当前 COVID-19 大流行的紧迫性、各种新突变株的检测以及新型冠状病毒未来可能再次出现的可能性，伊维菌素等已批准药物的再利用可能值得关注。这篇基于证据的评论文章旨在讨论伊维菌素对 SARS-CoV-2 的作用机制，并总结多年来的可用文献。已经提出了伊维菌素、宿主细胞和 SARS-CoV-2 在 COVID-19 发病机制和预防并发症中的关键细胞和生物分子相互作用的示意图。