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Estrogen-Like Substances from the Aerial Part of Ferula tschimganica
Pharmaceutical Chemistry Journal ( IF 0.9 ) Pub Date : 2021-06-15 , DOI: 10.1007/s11094-021-02408-x
A. U. Mamatkhanov , Kh. A. Akhmedkhodjaeva , M. A. Mamatkhanova , R. M. Khalilov

The optimal parameters influencing the extraction of the sum of terpenoid alcohol esters from the aerial part of Ferula tschimganica and purification of the obtained extract were found and made it possible to produce a final substance without green coloration. The technology for producing the sum of terpenoid alcohol esters from the aerial part of F. tschimganica was developed. Aspectrophotometric method for quantitative determination of the sum of terpenoid alcohol esters in chimphestrol substance (working name of the created agent) was proposed. Pharmacological studies found that terpenoid alcohol esters from the aerial part of F. tschimganica at a dose of 1 mg/kg exhibited a pronounced estrogenic effect in experiments on both immature and ovariectomized rats that was comparable to that of tefestrol and slightly inferior to that of the synthetic estrogenic drug Synestrol.



中文翻译:

来自 Ferula tschimganica 空中部分的雌激素样物质

找到了影响从Ferula tschimganica地上部分提取萜类醇酯总量和纯化所得提取物的最佳参数,并使得生产没有绿色着色的最终物质成为可能。开发了从柴胡地上部分制备总萜醇酯的技术。提出了一种分光光度法定量测定黑猩猩甾醇类物质中萜类醇酯的总量(所制备试剂的工名)。药理研究发现,来自F. tschimganica地上部分的萜类醇酯 在对未成熟和去卵巢大鼠的实验中,1 mg/kg 的剂量显示出明显的雌激素作用,与 tefestrol 相当,略逊于合成雌激素药物 Synestrol。

更新日期:2021-06-15
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