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Efficacy of repeated intravenous tranexamic acid in reducing perioperative bleeding of acetabular fractures
Clinical Hemorheology and Microcirculation ( IF 2.1 ) Pub Date : 2021-06-12 , DOI: 10.3233/ch-211203
Chen Xu 1 , Min Wu 2 , Zhaodong Wang 2 , Yajun Liu 2 , Pinghui Zhou 2 , Jianzhong Guan 1, 2
Affiliation  

BACKGROUND:Application of tranexamic acid (TXA) in the treatment of acetabular fractures could reduce intraoperative and postoperative blood loss. OBJECTIVE:To investigate the effect of single and repeated intravenous infusion of TXA on blood loss of acetabular fractures. METHODS:120 patients withacetabular fractures admitted to our hospital from January 2017 to September 2020 were retrospectively divided into three groups: Patients accepted 1g TXA at preoperative 30 minutes were defined as single TXA group (n = 40); Patients accepted 1g TXA at preoperative 30 minutes and 1g TXA at 3 hours after the start of surgery were defined as repeated TXA group (n = 40); Patients accepted normal saline at preoperative 30 minutes were defined as control group (n = 40). RESULTS:The total blood loss in single TXA group and repeated TXA group were significantly lower than control group, and the total blood loss in the repeated TXA group was significantly lower than single TXA group (P < 0.05). The hidden blood loss from surgery to postoperative 1 day in repeated TXA group was significantly lower than single TXA group and the control group(P < 0.05). No significant differences were observed in the operative time, postoperative transfusion rate and thrombosis rate among the three groups (P > 0.05). CONCLUSION:Repeated TXA is more recommended during acetabular fracture surgery since it can reduce the total blood loss without increasing the operative time, postoperative transfusion rate and thrombosis rate compared with single TXA.

中文翻译:

反复静脉注射氨甲环酸减少髋臼骨折围手术期出血的疗效

背景:应用氨甲环酸(TXA)治疗髋臼骨折可减少术中和术后失血量。目的:探讨单次和重复静脉滴注TXA对髋臼骨折出血量的影响。方法:将2017年1月至2020年9月我院收治的120例髋臼骨折患者回顾性分为3组:术前30 min接受1g TXA的患者定义为单次TXA组(n=40);术前30分钟接受1g TXA和手术开始后3小时接受1g TXA的患者定义为重复TXA组(n=40);术前30分钟接受生理盐水的患者定义为对照组(n = 40)。结果:单次TXA组和重复TXA组总失血量显着低于对照组,重复TXA组总失血量显着低于单次TXA组(P < 0.05)。TXA重复组手术至术后1天的隐性失血量显着低于TXA单药组和对照组(P < 0.05)。三组手术时间、术后输血率、血栓形成率比较,差异无统计学意义(P>0.05)。结 TXA重复组总失血量显着低于TXA单药组(P < 0.05)。TXA重复组手术至术后1天的隐性失血量显着低于TXA单药组和对照组(P < 0.05)。三组手术时间、术后输血率、血栓形成率比较,差异无统计学意义(P>0.05)。结 TXA重复组总失血量显着低于TXA单药组(P < 0.05)。TXA重复组手术至术后1天的隐性失血量显着低于TXA单药组和对照组(P < 0.05)。三组手术时间、术后输血率、血栓形成率比较,差异无统计学意义(P>0.05)。结 TXA重复组手术至术后1天的隐性失血量显着低于TXA单药组和对照组(P < 0.05)。三组手术时间、术后输血率、血栓形成率比较,差异无统计学意义(P>0.05)。结 TXA重复组手术至术后1天的隐性失血量显着低于TXA单药组和对照组(P < 0.05)。三组手术时间、术后输血率、血栓形成率比较,差异无统计学意义(P>0.05)。结
更新日期:2021-06-15
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