Right ventricular dysfunction is a hallmark of advanced pulmonary vascular, lung parenchymal, and left heart disease, yet the underlying mechanisms that govern (mal)adaptation remain incompletely characterized. Owing to the knowledge gaps in our understanding of the right ventricle (RV) in health and disease, the National Heart, Lung, and Blood Institute commissioned a working group to identify current challenges in the field. These included a need to define and standardize normal RV structure and function in populations; access to RV tissue for research purposes and the development of complex experimental platforms that recapitulate the in vivo environment; and the advancement of imaging and invasive methodologies to study the RV within basic, translational, and clinical research programs. Specific recommendations were provided, including a call to incorporate precision medicine and innovations in prognosis, diagnosis, and novel RV therapeutics for patients with pulmonary vascular disease.

中文翻译：

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肺血管疾病右心衰竭的诊断和治疗：国家心、肺和血液研究所研讨会

右心室功能障碍是晚期肺血管、肺实质和左心疾病的标志，但控制（不良）适应的潜在机制仍不完全清楚。由于我们对健康和疾病中的右心室 (RV) 的理解存在知识差距，国家心肺血液研究所委托成立了一个工作组来确定该领域当前的挑战。其中包括需要定义和标准化人群中正常的 RV 结构和功能；出于研究目的获取 RV 组织并开发重现体内环境的复杂实验平台；以及在基础、转化和临床研究项目中研究 RV 的成像和侵入性方法的进步。会议提出了具体建议，包括呼吁将精准医疗和创新应用于肺血管疾病患者的预后、诊断和新型 RV 疗法。