Aims

We aimed to compare renal sinus fat volume assessed by MRI between patients with type 2 diabetes and healthy volunteers, and investigate the association between renal sinus fat and metabolic traits.

Methods

In this cross-sectional study, renal sinus fat and parenchyma volumes measured on abdominal MRI were compared between patients and controls using analysis of covariance. Associations of renal parameters with clinical characteristics were analyzed using linear regression analysis.

Results

A total of 146 participants were enrolled, consisting of 95 type 2 diabetes patients (57.2 ± 8.8 years, 49.5% male) and 51 controls (54.0 ± 9.2 years, 43.1% male). Patients with diabetes demonstrated larger sinus fat volumes (15.4 ± 7.5 cm³ vs. 10.3 ± 7.1 cm³, p < 0.001) and sinus fat-parenchyma ratio than controls. In the total population, renal sinus fat was positively associated with HbA1c, abdominal VAT, cholesterol and triglycerides, after adjustment for age, sex, ethnicity and type 2 diabetes. In type 2 diabetes patients, increased sinus fat volume was significantly associated with urinary albumin-to-creatinine ratio.

Conclusion

Renal sinus fat volume is positively associated with several metabolic risk factors including HbA1c level and urinary albumin-to-creatinine ratio in type 2 diabetes patients, indicating a potential role of renal sinus fat in the development of diabetic nephropathy. Future studies are needed to investigate whether sinus fat volume can serve as an early biomarker for diabetic nephropathy.

中文翻译：

---

2型糖尿病肾窦脂肪体积与糖化血红蛋白和代谢危险因素相关

目标

我们旨在比较 2 型糖尿病患者和健康志愿者之间通过 MRI 评估的肾窦脂肪体积，并研究肾窦脂肪与代谢特征之间的关联。

方法

在这项横断面研究中，使用协方差分析比较了患者和对照组在腹部 MRI 上测量的肾窦脂肪和实质体积。使用线性回归分析分析肾脏参数与临床特征的关联。

结果

共招募了 146 名参与者，其中包括 95 名 2 型糖尿病患者（57.2  ±  8.8 岁，49.5% 男性）和 51 名对照者（54.0  ±  9.2 岁，43.1% 男性）。糖尿病患者表现出更大的鼻窦脂肪体积（15.4  ±  7.5  cm ³ vs. 10.3  ±  7.1  cm ³，p  < 0.001) 和窦脂肪 - 实质比率比对照组。在调整了年龄、性别、种族和 2 型糖尿病后，在总人群中，肾窦脂肪与 HbA1c、腹部增值税、胆固醇和甘油三酯呈正相关。在 2 型糖尿病患者中，增加的鼻窦脂肪体积与尿白蛋白与肌酐比显着相关。

结论

肾窦脂肪体积与 2 型糖尿病患者的多种代谢危险因素（包括 HbA1c 水平和尿白蛋白与肌酐比）呈正相关，表明肾窦脂肪在糖尿病肾病发展中的潜在作用。未来的研究需要调查窦脂肪体积是否可以作为糖尿病肾病的早期生物标志物。