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Pituitary volume in people with chronic schizophrenia: Clarifying the roles of serious violence and childhood maltreatment
Psychiatry Research: Neuroimaging ( IF 2.3 ) Pub Date : 2021-06-15 , DOI: 10.1016/j.pscychresns.2021.111323
Minal Bipin 1 , Preethi Premkumar 2 , Mrigendra K Das 3 , Jennifer Yf Lau 4 , Alex L Sumich 5 , Veena Kumari 6
Affiliation  

Aberrations in stress-linked hypothalamic-pituitary-adrenal axis function have been independently associated with schizophrenia, antisocial behaviour and childhood maltreatment. In this study, we examined pituitary volume (PV) in relation to childhood maltreatment (physical abuse, sexual abuse, neglect) in men (i) with schizophrenia and a history of serious violence (n = 13), (ii) with schizophrenia but without a history of serious violence (n = 15), (iii) with antisocial personality disorder (ASPD) and a history of serious violence (n = 13), and (iv) healthy participants without a history of violence (n = 15). All participants underwent whole-brain magnetic resonance imaging. Experiences of childhood maltreatment were rated based on interviews (for all), and case history and clinical/forensic records (for patients only). There was a trend for smaller PV, on average, in schizophrenia patients (regardless of a history of violence), compared to the healthy group and the ASPD group; other group differences in PV were non-significant. Sexual abuse ratings correlated negatively with PVs in ASPD participants, but no significant association between childhood maltreatment and PV was found in schizophrenia participants. Our findings are consistent with previous evidence of smaller-than-normal PV in chronic schizophrenia patients, and suggest that illness-related influences may mask the possible sexual abuse-smaller PV association, seen here in ASPD, in this population.



中文翻译:

慢性精神分裂症患者的垂体体积:阐明严重暴力和儿童虐待的作用

与压力相关的下丘脑-垂体-肾上腺轴功能异常与精神分裂症、反社会行为和儿童期虐待独立相关。在这项研究中,我们检查了与儿童期虐待(身体虐待、性虐待、忽视)相关的垂体体积 (PV) (i) 患有精神分裂症和严重暴力史的男性 ( n  = 13),(ii) 患有精神分裂症但没有严重暴力史 ( n  = 15),(iii) 有反社会人格障碍 (ASPD) 和严重暴力史 ( n  = 13),以及 (iv) 没有暴力史的健康参与者 ( n = 15)。所有参与者都接受了全脑磁共振成像。儿童虐待经历是根据访谈(对所有人)、病例史和临床/法医记录(仅对患者)进行评级的。与健康组和 ASPD 组相比,精神分裂症患者(无论是否有暴力史)平均有更小的 PV 趋势;PV 的其他组差异不显着。性虐待评级与 ASPD 参与者的 PV 呈负相关,但在精神分裂症参与者中未发现童年虐待与 PV 之间存在显着关联。我们的研究结果与之前慢性精神分裂症患者 PV 小于正常值的证据一致,并表明疾病相关的影响可能掩盖了可能的性虐待 - 较小的 PV 关联,见于 ASPD,

更新日期:2021-06-29
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