当前位置: X-MOL 学术Curr. Med. Res. Opin. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Determination of risk factors associated with inflammation in hypertensive patients with type-2 diabetes mellitus in a Palestinian Diabetes Study
Current Medical Research and Opinion ( IF 2.3 ) Pub Date : 2021-06-24 , DOI: 10.1080/03007995.2021.1941826
Mohammed S Ellulu 1 , Ihab A Naser 1 , Sahar M Abuhajar 2 , Ahmed A Najim 3
Affiliation  

Abstract

Objective

To determine the risk factors associated with inflammation in hypertensive patients with type-2 diabetes mellitus.

Methods

A total of 164 hypertensive patients with type 2 diabetes patients aged 38–60 years were selected from 7 primary healthcare centers in Gaza city, Palestine. Interview questionnaire were employed to collect data related to age, gender, smoking habits, and physical activity pattern. Laboratory biochemical tests included fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), interleukin 6 (IL-6), high sensitive C reactive protein (hs-CRP), and adiponectin were estimated in all patients.

Results

The study involved 118 (72%) women and 46 (28%) men; the mean of age was 53.7 ± 0.46 years. A tertile of inflammation feature with hs-CRP was developed. The highest tertile of hs-CRP was significantly associated with women, higher obesity indices, metabolic dysregulation involving lipid profile markers, FBG and blood pressure, IL-6, and lower adiponectin. After adjusting for age, gender, smoking habits, and physical activity; the risk factor of high level of hs-CRP were the increased body mass index [OR: 1.17, p = .018], IL-6 [OR: 2.22, p = .025] and FBG [OR: 1.01, p = .007], as well as reduced adiponectin [OR: 0.81, p = .002].

Conclusion

The inflammation state was affected by obesity and had been related to altered adipokines levels of IL-6 and adiponectin, as well as affected by the glycemic control, as evidenced by higher serum level of FBG.



中文翻译:

在巴勒斯坦糖尿病研究中确定与 2 型糖尿病高血压患者炎症相关的危险因素

摘要

客观的

确定与 2 型糖尿病高血压患者炎症相关的危险因素。

方法

从巴勒斯坦加沙市的 7 个初级卫生保健中心共选择了 164 名年龄在 38-60 岁之间的高血压合并 2 型糖尿病患者。采用访谈问卷收集与年龄、性别、吸烟习惯和身体活动模式相关的数据。实验室生化检测包括空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、白细胞介素6(IL-6)、高敏C反应蛋白(hs-CRP)和脂联素。

结果

该研究涉及 118 (72%) 名女性和 46 (28%) 名男性;平均年龄为 53.7 ± 0.46 岁。开发了具有 hs-CRP 的三分位数炎症特征。hs-CRP 的最高三分位数与女性、较高的肥胖指数、涉及脂质特征标志物、FBG 和血压、IL-6 和较低脂联素的代谢失调显着相关。在调整年龄、性别、吸烟习惯和身体活动后;高水平 hs-CRP 的危险因素是增加的体重指数 [OR: 1.17, p  = .018]、IL-6 [OR: 2.22, p  = .025] 和 FBG [OR: 1.01, p  = . 007],以及减少的脂联素 [OR:0.81,p  = .002]。

结论

炎症状态受肥胖影响,并与 IL-6 和脂联素的脂肪因子水平改变有关,也受血糖控制的影响,如血清 FBG 水平升高所证明的那样。

更新日期:2021-08-24
down
wechat
bug