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Simulation of Fluid-Structure Interaction in Extracorporeal Membrane Oxygenation Circulatory Support Systems
Journal of Cardiovascular Translational Research ( IF 3.4 ) Pub Date : 2021-06-14 , DOI: 10.1007/s12265-021-10143-7
Farhad R Nezami 1, 2 , Mehdi Ramezanpour 3 , Farhan Khodaee 1 , Efrat Goffer 1 , Elazer R Edelman 1, 4 , Steven P Keller 1, 5
Affiliation  

Extracorporeal membrane oxygenation (ECMO) is a vital mechanical circulatory support modality capable of restoring perfusion for the patient in circulatory failure. Despite increasing adoption of ECMO, there is incomplete understanding of its effects on systemic hemodynamics and how the vasculature responds to varying levels of continuous retrograde perfusion. To gain further insight into the complex ECMO:failing heart circulation, computational fluid dynamics simulations focused on perfusion distribution and hemodynamic flow patterns were conducted using a patient-derived aorta geometry. Three case scenarios were simulated: (1) healthy control; (2) 90% ECMO-derived perfusion to model profound heart failure; and, (3) 50% ECMO-derived perfusion to model the recovering heart. Fluid-structure interface simulations were performed to quantify systemic pressure and vascular deformation throughout the aorta over the cardiac cycle. ECMO support alters pressure distribution while decreasing shear stress. Insights derived from computational modeling may lead to better understanding of ECMO support and improved patient outcomes.



中文翻译:

体外膜氧合循环支持系统流固耦合模拟

体外膜肺氧合(ECMO)是一种重要的机械循环支持方式,能够为循环衰竭的患者恢复灌注。尽管越来越多地采用 ECMO,但对其对全身血流动力学的影响以及脉管系统如何响应不同水平的连续逆行灌注的了解尚不完全。为了进一步了解复杂的 ECMO:心脏循环衰竭,使用源自患者的主动脉几何结构进行了专注于灌注分布和血液动力学流动模式的计算流体动力学模拟。模拟了三种情况:(1)健康对照;(2) 90% ECMO 衍生的灌注来模拟严重心力衰竭;(3) 50% ECMO 衍生的灌注来模拟恢复中的心脏。进行流固界面模拟以量化心动周期内整个主动脉的全身压力和血管变形。ECMO 支持改变压力分布,同时降低剪切应力。从计算模型中得出的见解可能会有助于更好地理解 ECMO 支持并改善患者的治疗效果。

更新日期:2021-06-15
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