The life and work of crystallography pioneer Isabella L. Karle is recounted (1921–2017), as researched from the literature and personal stories of colleagues and family. Her story includes her family background, education at the University of Michigan, research on the Manhattan Project, and 63 productive years at the Naval Research Laboratory. Her life-long partnership and scientific collaboration with husband Jerome Karle, 1985 Nobel Prize winner in Chemistry with Herbert Hauptman, is a big part of her story; however, Isabella has also established herself as a crystallographer extraordinaire through her Symbolic Addition Procedure to solve the phase problem, and her unique ability to solve the structures of complex biological molecules, including toxins, antibiotics, and peptides. Her rich family life with three daughters in a lake-front home, do-it-yourself attitude, and passions outside of science round up this portrait of a fascinating and brilliant woman.

中文翻译：

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Isabella L. Karle：晶体学先驱

根据文献以及同事和家人的个人故事，叙述了晶体学先驱伊莎贝拉·卡尔勒 (Isabella L. Karle) 的生活和工作（1921-2017 年）。她的故事包括她的家庭背景、在密歇根大学接受的教育、曼哈顿计划的研究以及在海军研究实验室的 63 年富有成果的经历。她与丈夫杰罗姆·卡勒 (Jerome Karle) 的终生伙伴关系和科学合作是她故事的重要组成部分，杰罗姆·卡勒是 1985 年诺贝尔化学奖得主，与赫伯特·豪普特曼 (Herbert Hauptman) 合作。然而，伊莎贝拉也确立了自己作为杰出晶体学家的地位通过她的符号加法程序来解决相位问题，以及她解决复杂生物分子结构（包括毒素、抗生素和肽）的独特能力。她与三个女儿在湖边的家中过着富裕的家庭生活，自己动手的态度，以及科学之外的热情，构成了这位迷人而才华横溢的女性的肖像。