Nonlesional diffusely abnormal appearing white matter in clinically isolated syndrome: Prevalence, association with clinical and MRI features, and risk for conversion to multiple sclerosis,Journal of Neuroimaging

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Nonlesional diffusely abnormal appearing white matter in clinically isolated syndrome: Prevalence, association with clinical and MRI features, and risk for conversion to multiple sclerosis
Journal of Neuroimaging ( IF 2.4 ) Pub Date : 2021-06-15 , DOI: 10.1111/jon.12900
R Davis Holmes ₁ , Irene M Vavasour ₁ , Jamie Greenfield ₂ , Guojun Zhao _{1,

3} , Jimmy S Lee ₁ , G R Wayne Moore _{4,

5} , Roger Tam _{1,

3,

6} , Luanne M Metz ₂ , Anthony Trablousee _{3,

7} , David K B Li _{1,

3,

7} , Cornelia Laule _{1,

4,

5,

8}

Affiliation

While diffusely abnormal white matter (DAWM) is a nonlesional MRI abnormality identified in ∼25% of patients with multiple sclerosis (MS), it has yet to be investigated in patients at an earlier disease stage, namely clinically isolated syndrome (CIS). The goals of this study were to (1) determine the prevalence of DAWM in patients with a CIS suggestive of MS, (2) evaluate the association between DAWM and demographic, clinical, and MRI features, and (3) evaluate the prognostic significance of DAWM on conversion from CIS to MS.

中文翻译：

临床孤立综合征中出现非病变性弥漫性异常白质：患病率、与临床和 MRI 特征的关联以及转化为多发性硬化症的风险

虽然弥漫性异常白质 (DAWM) 是一种在约 25% 的多发性硬化症 (MS) 患者中发现的非病变 MRI 异常，但尚未在早期疾病阶段的患者中进行研究，即临床孤立综合征 (CIS)。本研究的目标是 (1) 确定提示 MS 的 CIS 患者中 DAWM 的患病率，(2) 评估 DAWM 与人口统计学、临床和 MRI 特征之间的关联，以及 (3) 评估预后意义。 DAWM 关于从 CIS 到 MS 的转换。

更新日期：2021-06-15

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