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Thermally-actuated microfluidic membrane valve for point-of-care applications
Microsystems & Nanoengineering ( IF 7.9 ) Pub Date : 2021-06-15 , DOI: 10.1038/s41378-021-00260-3
Muhsincan Sesen 1 , Christopher J Rowlands 1
Affiliation  

Microfluidics has enabled low volume biochemistry reactions to be carried out at the point-of-care. A key component in microfluidics is the microfluidic valve. Microfluidic valves are not only useful for directing flow at intersections but also allow mixtures/dilutions to be tuned real-time and even provide peristaltic pumping capabilities. In the transition from chip-in-a-lab to lab-on-a-chip, it is essential to ensure that microfluidic valves are designed to require less peripheral equipment and that they are transportable. In this paper, a thermally-actuated microfluidic valve is presented. The valve itself is fabricated with off-the-shelf components without the need for sophisticated cleanroom techniques. It is shown that multiple valves can be controlled and operated via a power supply and an Arduino microcontroller; an important step towards transportable microfluidic devices capable of carrying out analytical assays at the point-of-care. It is been calculated that a single actuator costs less than $1, this highlights the potential of the presented valve for scaling out. The valve operation is demonstrated by adjusting the ratio of a water/dye mixture in a continuous flow microfluidic chip with Y-junction channel geometry. The power required to operate one microfluidic valve has been characterised both theoretically and experimentally. Cyclical operation of the valve has been demonstrated for 65 h with 585 actuations. The presented valve is capable of actuating rectangular microfluidic channels of 500 μm × 50 μm with an expected temperature increase of up to 5 °C. The fastest actuation times achieved were 2 s for valve closing (heating) and 9 s for valve opening (cooling).



中文翻译:

适用于护理点应用的热驱动微流控薄膜阀

微流体技术使得小体积的生物化学反应能够在护理点进行。微流控的关键部件是微流控阀。微流体阀不仅可用于引导交叉点处的流动,而且还允许实时调整混合物/稀释液,甚至提供蠕动泵送功能。在从实验室芯片到芯片实验室的转变中,必须确保微流阀的设计需要较少的外围设备并且可运输。在本文中,提出了一种热驱动微流阀。阀门本身采用现成组件制造,无需复杂的洁净室技术。结果表明,可以通过电源和Arduino微控制器控制和操作多个阀门;这是朝着能够在护理点进行分析测定的可移动微流体设备迈出的重要一步。据计算,单个执行器的成本不到 1 美元,这凸显了所提出的阀门的扩展潜力。通过调节具有 Y 形连接通道几何形状的连续流微流控芯片中水/染料混合物的比例来演示阀门的操作。操作一个微流体阀所需的功率已在理论上和实验上得到表征。阀门的循环操作已被证明 65 小时、585 次驱动。该阀门能够驱动 500 μm × 50 μm 的矩形微流体通道,预计温度升高高达 5 °C。阀门关闭(加热)的最快驱动时间为 2 秒,阀门打开(冷却)的最快驱动时间为 9 秒。

更新日期:2021-06-15
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