Iron (Fe) and Fe-based scaffolds have become a research frontier in absorbable materials which is inherent to their promising mechanical properties including fatigue strength and ductility. Nevertheless, their slow corrosion rate and low biocompatibility have been their major obstacles to be applied in clinical applications. Over the last decade, various modifications on porous Fe-based scaffolds have been performed to ameliorate both properties encompassing surface coating, microstructural alteration via alloying, and advanced topologically order structural design produced by additive manufacturing (AM) techniques. The recent advent of AM produces topologically ordered porous Fe-based structures with an optimized architecture having controllable pore size and strut thickness, intricate internal design, and larger exposed surface area. This undoubtedly opens up new options for controlling Fe corrosion and its structural strengths. However, the in vitro biocompatibility of the AM porous Fe still needs to be addressed considering its higher corrosion rate due to the larger exposed surface area. This review summarizes the latest progress of the modifications on porous Fe-based scaffolds with a specific focus on their responses on the corrosion behavior and biocompatibility.

中文翻译：

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用于骨应用的多孔可吸收铁基支架的改性：腐蚀和生物相容性观点的综述

铁 (Fe) 和 Fe 基支架已成为可吸收材料的研究前沿，这是其具有前景的机械性能（包括疲劳强度和延展性）所固有的。然而，它们缓慢的腐蚀速率和低的生物相容性一直是它们在临床应用中的主要障碍。在过去的十年中，已经对多孔铁基支架进行了各种修改，以改善包括表面涂层、通过合金化来改变微观结构以及通过增材制造 (AM) 技术产生的先进拓扑有序结构设计等两种特性。AM 的最新出现产生了拓扑有序的多孔铁基结构，该结构具有优化的结构，具有可控的孔径和支柱厚度、复杂的内部设计和更大的暴露表面积。这无疑为控制 Fe 腐蚀及其结构强度开辟了新的选择。然而，AM 多孔铁的体外生物相容性仍然需要解决，因为由于暴露表面积较大，其腐蚀速率较高。本综述总结了多孔铁基支架改性的最新进展，特别关注它们对腐蚀行为和生物相容性的反应。