The solubility of pyridine-2,6-dicarboxylic acid in supercritical carbon dioxide was measured at 313–333 K and 10–20 MPa, using a flow-saturation technique. The influence of methanol on solubility behavior is investigated. The solubility in neat supercritical carbon dioxide ranged from 0.44 × 10⁻⁶ mol·moltot⁻¹ to 3.4 × 10⁻⁶ mol·moltot⁻¹_, while its solubility in presence of methanol ranged from 0.17 × 10⁻⁵ mol·moltot⁻¹ to 18.1 × 10⁻⁵ mol·moltot⁻¹. The solubility data was modeled with Chrastil, Mendez-Teja, Garlapati equations and Peng-Robinson equation of state model. The solubility in the presence of methanol was correlated using modified Chrastil, modified Mendez-Teja and Thakur models. Among the models employed, Chrastil model (binary system) and modified Mendez-Teja model (ternary system) shown highest accordance with experimental data. Pyridine-2,6-dicarboxylic acid was employed as a chelating agent for development of a supercritical fluid extraction method for removal of Pb²⁺ and Ni²⁺ from simulated aqueous/soil matrices.

使用流动饱和技术在 313-333 K 和 10-20 MPa 下测量吡啶-2,6-二羧酸在超临界二氧化碳中的溶解度。研究了甲醇对溶解行为的影响。在纯超临界二氧化碳中的溶解度为0.44×10 ^-6 mol·moltot ^-1至3.4×10 ^-6 mol·moltot ^-1 _，而在甲醇存在下的溶解度为0.17×10 ^-5 mol·moltot ^-1至 18.1 × 10 ^-5 mol·moltot ^-1. 溶解度数据用 Chrastil、Mendez-Teja、Garlapati 方程和 Peng-Robinson 状态模型方程建模。使用改进的 Chrastil、改进的 Mendez-Teja 和 Thakur 模型关联甲醇存在下的溶解度。在采用的模型中，Chrastil 模型（二元系统）和修正的 Mendez-Teja 模型（三元系统）与实验数据的一致性最高。吡啶-2,6-二羧酸被用作螯合剂，用于开发从模拟水/土壤基质中去除Pb ²⁺和Ni ²⁺的超临界流体萃取方法。