• A novel injectable double-layer-gel matrix is developed.

• The hierarchically structured dual lipid gel matrix enables time-programmed drug delivery.

• Applying a modest dose of sorafenib in advance can reeducate tumor-associated macrophages and potentiate anti-CD47 treatment.

中文翻译：

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通过双层凝胶基质定时递送索拉非尼和抗 CD47 抗体用于乳腺癌的术后治疗

• 开发了一种新型可注射双层凝胶基质。

• 分层结构的双脂质凝胶基质可实现时间程序化药物输送。

• 提前应用适度剂量的索拉非尼可以再教育肿瘤相关巨噬细胞并加强抗 CD47 治疗。