Candida yeasts are the most frequent in the vaginal content. This yeast may be a normal microbiota but also causes candidiasis. In symptomatic cases, primary candidiasis (VVC) or recurrence (RVVC) can be considered. This study aims to compare the frequency and in vitro sensitivity profile of Candida species isolated in the vaginal content with the different stages of the presence of yeasts. A total of 258 non-pregnant patients with/without VVC were prospectively screened at a teaching Health Centre of the Faculty of Medicine, in the University of Sao Paulo. The vaginal isolates were identified by traditional and molecular methods. Yeasts were isolated in 160 women. 34% were asymptomatic, 34% with vulvovaginal candidiasis (VVC), and 32% recurrent vulvovaginal candidiasis (RVVC). C. albicans was the most frequent species with 50.1% (82/160), followed by C. parapsilosis 13.7%(22/160), C. glabrata 12.5% (20/160), and C. tropicalis (6.2%). Analysis by the group showed that, in the asymptomatic group, eight yeast species were isolated, C. albicans 44.5% (24/54), C. glabrata 20% (11/54), C. parapsilosis and Rhodotorula rubra being the most frequent. In the VVC group, 11 yeast species were identified. Most isolates were C. albicans 68.5% (37/54), C. tropicalis 7.5% (4/54), and C. parapsilosis 5.5% (3/54). In the RVVC group, ten species were identified, the most frequent being C. albicans 38.5% (20/52), C. parapsilosis 17% (9/52), C. glabrata 4% (8/52), and C. tropicalis 6% (3/52). Less frequent species, such as C. haemulonii and Trichosporon spp, were isolated in the VVC and RVVC groups, C. kefyr was isolated in the three groups studied, and Rhodotorula spp was isolated in the control and RVVC groups. Candida metapsilosis was present in two isolates from the RVVC group. Most isolates were considered sensitive to the tested antifungals. Less sensitivity was seen for caspofungin. In this study, we were able to verify that the most common species of yeasts found in vaginal secretion were isolated in the three groups studied; however, there was the diversity of species in VVC and RVVC. Cryptic species C. haemulonii and were isolated in symptomatic patients. High levels of MICs, some of the antifungals tested, in the control group, draw attention in the group of asymptomatic women. We would like to emphasize that this research aims to assist clinicians and gynecologists, as well as assist in the epidemiological studies of candidiasis, in our country, how to draw attention to the profile of sensitivity/resistance to antifungals.

念珠菌酵母是阴道内容物中最常见的。这种酵母可能是一种正常的微生物群，但也会引起念珠菌病。在有症状的情况下，可以考虑原发性念珠菌病 (VVC) 或复发 (RVVC)。本研究旨在比较阴道内容物中分离出的念珠菌种类的频率和体外敏感性与酵母存在的不同阶段。在圣保罗大学医学院的教学健康中心对总共 258 名有/没有 VVC 的非妊娠患者进行了前瞻性筛查。通过传统和分子方法鉴定阴道分离物。在 160 名女性中分离出酵母菌。34% 无症状，34% 有外阴阴道念珠菌病 (VVC)，32% 有复发性外阴阴道念珠菌病 (RVVC)。白色念珠菌是最常见的物种，占 50.1% (82/160)，其次是近平滑念珠菌13.7% (22/160)、光滑念珠菌12.5% (20/160) 和热带念珠菌(6.2%)。该小组的分析表明，在无症状组中，分离出8种酵母菌，白色念珠菌44.5%（24/54），光滑念珠菌20%（11/54），最常见的是近平滑念珠菌和红酵母. 在 VVC 组中，鉴定了 11 种酵母菌。大多数分离株为白色念珠菌 68.5% (37/54)、热带念珠菌7.5% (4/54) 和近平滑念珠菌 5.5%(3/54)。在 RVVC 组中，鉴定出 10 个物种，最常见的是白色念珠菌38.5% (20/52)、近平滑念珠菌17% (9/52)、光滑念珠菌4% (8/52) 和C.热带6% (3/52)。较不频繁的物种，如C. haemulonii和丝孢菌属，在VVC和RVVC组，分离C.乳酒在所研究的三组中分离，和红酵母属是在控制和RVVC组隔离。化生念珠菌存在于来自 RVVC 组的两个分离株中。大多数分离株被认为对测试的抗真菌剂敏感。对卡泊芬净的敏感性较低。在这项研究中，我们能够验证在所研究的三组中分离出阴道分泌物中最常见的酵母菌种类；然而，VVC和RVVC存在物种多样性。隐性物种C. haemulonii 并在有症状的患者中分离。对照组中高水平的 MIC（一些测试的抗真菌药）引起了无症状女性组的注意。我们想强调的是，这项研究旨在协助临床医生和妇科医生，以及协助我国念珠菌病的流行病学研究，如何引起人们对抗真菌药敏感性/耐药性的关注。