Increased bacterial resistance to antibiotics is a major threat to human health, and it is particularly important to develop novel antibiotic drugs. Here, we designed a series of Schiff base thiosemicarbazone derivatives containing an adamantane moiety, and carried out the structural characterization of the compounds and in vitro antibacterial activity tests. Compound 7e was as effective as the commonly used antibiotic ampicillin against the Gram-negative bacterium Escherichia coli, and compound 7g had a good inhibitory effect against Gram-positive Bacillus subtilis. These findings provide data for the development of better thiosemicarbazone antibacterial agents.

细菌对抗生素的耐药性增加是对人类健康的主要威胁，开发新型抗生素药物尤为重要。在这里，我们设计了一系列含有金刚烷部分的希夫碱缩氨基硫脲衍生物，并进行了化合物的结构表征和体外抗菌活性测试。化合物7e对革兰氏阴性菌大肠杆菌的作用与常用抗生素氨苄西林一样有效，化合物7g对革兰氏阳性菌枯草芽孢杆菌具有良好的抑制作用。这些发现为开发更好的缩氨基硫脲抗菌剂提供了数据。