The effectiveness of tannic acid as antimicrobial and wound healing for burns have been shown for a century; however, uncontrolled target dosage may result in undesirable side-effects. Remarkably, tannic acid polyphenols compounds crosslinked with polymeric materials produce a strong composite containing the beneficial properties of this tannin. However, investigation of the crosslink structure and its antibacterial and regenerative properties are still unknown when using nanocellulose by mechanical defibrillation; additionally, due to the potential crosslink structure with chitosan, its structure can be complex. Therefore, this work uses bleach kraft nanocellulose in order to investigate the effect on the physical and regenerative properties when incorporated with chitosan and tannic acid. This film results in increased rigidity with a lamellar structure when incorporated with tannic acid due to its strong hydrogen bonding. The release of tannic acid varied depending on the structure it was synthesised with, whereas with chitosan it presented good release model compared to pure cellulose. In addition, exhibiting similar thermal stability as pure cellulose films with antibacterial properties tested against S. aureus and E. coli with good metabolic cellular viability while also inhibiting NF-κB activity, a characteristic of tannic acid.

一个世纪以来，单宁酸作为烧伤的抗菌和伤口愈合的有效性已经得到证明。然而，不受控制的目标剂量可能会导致不良副作用。值得注意的是，与聚合物材料交联的单宁酸多酚化合物产生了一种坚固的复合材料，其中包含这种单宁的有益特性。然而，当通过机械除颤使用纳米纤维素时，对交联结构及其抗菌和再生性能的研究仍然未知。此外，由于与壳聚糖的潜在交联结构，其结构可能很复杂。因此，这项工作使用漂白牛皮纸纳米纤维素来研究与壳聚糖和单宁酸结合时对物理和再生特性的影响。由于其强大的氢键，当与单宁酸结合时，这种薄膜会增加层状结构的刚性。单宁酸的释放取决于其合成的结构，而与纯纤维素相比，壳聚糖具有良好的释放模型。此外，表现出与纯纤维素薄膜相似的热稳定性，并具有抗细菌性能测试金黄色葡萄球菌和大肠杆菌具有良好的代谢细胞活力，同时还能抑制 NF-κB 活性，这是单宁酸的特征。