The objective of this study was to determine primary prescription adherence for obstructive lung diseases (e.g., asthma, COPD) in an adult primary care patient population over a 3-year period. A retrospective analysis of electronic medical record and administrative data was performed to determine primary adherence, defined as dispensation of a new prescription within 90 days of the date the prescription was written. Multivariable logistic regression models were used to test predictors of prescription primary adherence. Of 13,220 prescriptions for obstructive airway disease, 75.9% (N = 10,038) were filled. In multivariate analysis, depression, certain age groups (18–44 years), higher income quartile were associated with reduced prescription adherence. However, 1–2 ER visits in the previous year (compared to no ER visits), number of ambulatory visits in the previous year, and number of hospitalizations in the previous year, did not increase the likelihood of prescription adherence. This study provides important insights about factors associated with prescription nonadherence and is the first study examining primary medication adherence with medications for obstructive lung disease in adults, providing indications of prescription nonadherence patterns among a broad population.

中文翻译：

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初级保健人群中阻塞性肺病的初级处方依从性

本研究的目的是确定成人初级保健患者群体在 3 年内对阻塞性肺疾病（例如哮喘、COPD）的初级处方依从性。对电子病历和管理数据进行回顾性分析以确定主要依从性，定义为在处方开具之日起 90 天内配发新处方。多变量逻辑回归模型用于测试处方主要依从性的预测因素。在 13,220 份阻塞性气道疾病处方中，75.9% (N = 10,038) 被填写。在多变量分析中，抑郁症、某些年龄组（18-44 岁）、较高的收入四分位数与处方依从性降低有关。然而，前一年有 1-2 次急诊就诊（与没有急诊就诊相比），上一年的门诊次数和上一年的住院次数并没有增加遵守处方的可能性。这项研究提供了关于与处方不依从相关因素的重要见解，并且是第一项研究成人阻塞性肺病药物对主要药物依从性的研究，提供了广泛人群中处方不依从模式的指征。