Skin is the most vulnerable organ of the human body since it is the first line of defense, covering the entire external body surface. Additionally, skin has a critical role in thermoregulation, sensation, immunological surveillance, and biochemical processes such as Vitamin D₃ production by ultraviolet irradiation. The ability of the skin layers and resident cells to maintain skin physiology, such as hydration, regulation of keratinocytes proliferation and differentiation and wound healing, is supported by key proteins such as aquaporins (AQPs) that facilitate the movements of water and small neutral solutes across membranes. Various AQP isoforms have been detected in different skin-resident cells where they perform specific roles, and their dysregulation has been associated with several skin pathologies. This review summarizes the current knowledge of AQPs involvement in skin physiology and pathology, highlighting their potential as druggable targets for the treatment of skin disorders.

皮肤是人体最脆弱的器官，因为它是第一道防线，覆盖了整个体外表面。此外，皮肤在体温调节、感觉、免疫监测和生化过程（如维生素 D _3）中起着关键作用通过紫外线照射生产。皮肤层和驻留细胞维持皮肤生理机能的能力，例如水合作用、角质形成细胞增殖和分化的调节以及伤口愈合，得到关键蛋白质的支持，例如水通道蛋白 (AQP)，这些蛋白质促进水和小的中性溶质穿过膜。已在不同的皮肤驻留细胞中检测到各种 AQP 同种型，它们在其中发挥特定作用，并且它们的失调与多种皮肤病理有关。本综述总结了 AQP 参与皮肤生理学和病理学的当前知识，强调了它们作为治疗皮肤病的药物靶点的潜力。