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Key Signaling Pathways Regulate the Development and Survival of Auditory Hair Cells
Neural Plasticity ( IF 3.1 ) Pub Date : 2021-06-12 , DOI: 10.1155/2021/5522717
Yao Liu 1, 2, 3, 4, 5 , Mei Wei 1, 2, 3, 4, 5 , Xiang Mao 1, 2, 3, 4, 5 , Taisheng Chen 1, 2, 3, 4, 5 , Peng Lin 1, 2, 3, 4, 5 , Wei Wang 1, 2, 3, 4, 5
Affiliation  

The loss of auditory sensory hair cells (HCs) is the most common cause of sensorineural hearing loss (SNHL). As the main sound transmission structure in the cochlea, it is necessary to maintain the normal shape and survival of HCs. In this review, we described and summarized the signaling pathways that regulate the development and survival of auditory HCs in SNHL. The role of the mitogen-activated protein kinase (MAPK), phosphoinositide-3 kinase/protein kinase B (PI3K/Akt), Notch/Wnt/Atoh1, calcium channels, and oxidative stress/reactive oxygen species (ROS) signaling pathways are the most relevant. The molecular interactions of these signaling pathways play an important role in the survival of HCs, which may provide a theoretical basis and possible therapeutic interventions for the treatment of hearing loss.

中文翻译:

关键信号通路调节听觉毛细胞的发育和存活

听觉感觉毛细胞 (HC) 的损失是感音神经性听力损失 (SNHL) 的最常见原因。作为耳蜗内的主要传声结构,需要维持HCs的正常形态和存活。在这篇综述中,我们描述并总结了调节 SNHL 中听觉 HC 发育和存活的信号通路。丝裂原活化蛋白激酶 (MAPK)、磷酸肌醇 3 激酶/蛋白激酶 B (PI3K/Akt)、Notch/Wnt/Atoh1、钙通道和氧化应激/活性氧 (ROS) 信号通路的作用是最相关的。这些信号通路的分子相互作用在HCs的存活中发挥着重要作用,这可能为听力损失的治疗提供理论基础和可能的治疗干预。
更新日期:2021-06-13
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