Abstract

A complex of parameters of the blood system of BALB/c mice was studied using alkanes symmetrically and asymmetrically replaced with heterocyclic amines, which protected 85–100% of mice after total exposure to ¹³⁷Cs γ-radiation at the minimum lethal dose. The ability of substances of different structures to protect hematopoietic tissue in in vivo and in vitro experiments has been established. Differences in the rates of post-radiation repopulation of blood cells in protected mice were revealed, which are associated with the survival of the organism. It was found that the response to the effect of the investigated substances at the level of the organism (acute toxicity, anti-radiation activity, oxygen consumption by the body) and hematopoietic tissue (changes in cellularity in the hematopoietic organs and peripheral blood) depends on the structure of the substance (length of the aliphatic chain, acidic component).

中文翻译：

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新型二氨基烷烃及其添加剂盐在小鼠存活试验中有效保护急性放射病骨髓形式的血液系统的能力

摘要

使用对称和不对称取代杂环胺的烷烃研究了 BALB/c 小鼠血液系统参数的复合体，在完全暴露于¹³⁷最低致死剂量下的 Cs γ 辐射。不同结构的物质在体内外实验中对造血组织的保护能力已经确立。揭示了受保护小鼠中血细胞辐射后重新增殖率的差异，这与生物体的存活有关。发现在生物体（急性毒性、抗辐射活性、身体耗氧量）和造血组织（造血器官和外周血中细胞结构的变化）水平上对所研究物质的影响的反应取决于关于物质的结构（脂肪链的长度，酸性成分）。