当前位置: X-MOL 学术Nat. Rev. Neurol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Perinatal stroke: mapping and modulating developmental plasticity
Nature Reviews Neurology ( IF 38.1 ) Pub Date : 2021-06-14 , DOI: 10.1038/s41582-021-00503-x
Adam Kirton 1, 2, 3, 4, 5, 6 , Megan J Metzler 1, 3, 4, 5 , Brandon T Craig 1, 2, 3, 4 , Alicia Hilderley 1, 2, 3, 4 , Mary Dunbar 1, 2, 3, 4, 5 , Adrianna Giuffre 1, 2, 3, 4 , James Wrightson 1, 2, 3, 4 , Ephrem Zewdie 1, 2, 3, 4 , Helen L Carlson 1, 2, 3, 4
Affiliation  

Most cases of hemiparetic cerebral palsy are caused by perinatal stroke, resulting in lifelong disability for millions of people. However, our understanding of how the motor system develops following such early unilateral brain injury is increasing. Tools such as neuroimaging and brain stimulation are generating informed maps of the unique motor networks that emerge following perinatal stroke. As a focal injury of defined timing in an otherwise healthy brain, perinatal stroke represents an ideal human model of developmental plasticity. Here, we provide an introduction to perinatal stroke epidemiology and outcomes, before reviewing models of developmental plasticity after perinatal stroke. We then examine existing therapeutic approaches, including constraint, bimanual and other occupational therapies, and their potential synergy with non-invasive neurostimulation. We end by discussing the promise of exciting new therapies, including novel neurostimulation, brain–computer interfaces and robotics, all focused on improving outcomes after perinatal stroke.



中文翻译:

围产期中风:绘制和调节发育可塑性

大多数偏瘫性脑瘫病例是由围产期中风引起的,导致数百万人终生残疾。然而,我们对这种早期单侧脑损伤后运动系统如何发展的理解正在增加。神经成像和大脑刺激等工具正在生成围产期中风后出现的独特运动网络的信息图。作为在其他方面健康的大脑中定义时间的局灶性损伤,围产期中风代表了发育可塑性的理想人类模型。在这里,我们先介绍围产期卒中的流行病学和结局,然后再回顾围产期卒中后的发育可塑性模型。然后我们检查现有的治疗方法,包括约束、双手和其他职业疗法,以及它们与非侵入性神经刺激的潜在协同作用。我们最后讨论了令人兴奋的新疗法的前景,包括新型神经刺激、脑机接口和机器人技术,所有这些都专注于改善围产期卒中后的结果。

更新日期:2021-06-14
down
wechat
bug