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Evaluation of Electrocardiographic Parameters and the Presence of Interatrial Block in Patients with Mad Honey Intoxication
Cardiovascular Toxicology ( IF 3.2 ) Pub Date : 2021-06-14 , DOI: 10.1007/s12012-021-09668-9
Altuğ Ösken 1 , Ercan Aydın 2 , Kazım Serhan Özcan 1 , Selçuk Yaylacı 3, 4
Affiliation  

Mad honey intoxication (MHI) is a food-induced clinical condition that usually presents with cardiovascular symptoms and can lead to life-threatening arrhythmias if not diagnosed and treated early. No data exist in the literature on the presence of interatrial block (IAB) after food intoxication. In our study, we sought to investigate atrioventricular electrocardiography (ECG) parameters and determine the frequency of IAB in patients with MHI. In total, 76 patients diagnosed with MHI were included in our retrospective study. Twelve-lead ECGs were performed and participants were divided into two groups according to the presence of IAB in the reference ECG. The P maximum (Pmax), P minimum (Pmin), P dispersion (Pdisp), T peak to T end (Tp–Te) interval and QT dispersion (QTdisp) values were compared between the two groups. IAB was detected in 28 (35.5%) of 76 MHI patients included in the final analysis. Pmax duration (122 ± 8; p < 0.001) and PD (69 ± 11; p < 0.001) were significantly higher in the IAB ( +) group. During regression analysis, Pmax [odds ratio (OR) 1.158, 95% confidence interval (CI) 1.036–1.294; p = 0.010] and Pd (OR 1.086, 95% CI 1.001–1.017; p = 0.046) were independently associated with IAB. Pmax and Pd area under the receiver operating characteristic curve values for IAB prediction were 0.926 (95% CI 0.841–1,000; p < 0.001) and 0.872 (95% CI 0.765–0.974; p < 0.001), respectively. ECG changes are common in patients presenting with MHI. These patients need to be followed up clinically in terms of progression to arrhythmic events that may occur in the future.



中文翻译:

疯狂蜂蜜中毒患者心电图参数和房间传导阻滞的评估

疯狂蜂蜜中毒 (MHI) 是一种由食物引起的临床疾病,通常表现为心血管症状,如果不及早诊断和治疗,可能导致危及生命的心律失常。文献中没有关于食物中毒后出现心房传导阻滞 (IAB) 的数据。在我们的研究中,我们试图调查房室心电图 (ECG) 参数并确定 MHI 患者 IAB 的频率。总共有 76 名诊断为 MHI 的患者被纳入我们的回顾性研究。进行了 12 导联心电图,根据参考心电图中 IAB 的存在将参与者分为两组。P最大值(P max)、P最小值(P min)、P色散(P disp)、T 峰到 T 结束 (Tp-Te) 间隔和 QT 离散 (QT disp ) 值在两组之间进行比较。在最终分析的 76 名 MHI 患者中,有 28 名 (35.5%) 检测到 IAB。P max持续时间 (122 ± 8; p  < 0.001) 和 PD (69 ± 11; p  < 0.001) 在 IAB (+) 组中显着更高。在回归分析期间,P max [优势比 (OR) 1.158, 95% 置信区间 (CI) 1.036–1.294;p  = 0.010] 和 Pd (OR 1.086, 95% CI 1.001–1.017; p  = 0.046) 与 IAB 独立相关。IAB 预测的受试者工作特征曲线下的P max和 Pd 面积值为 0.926(95% CI 0.841–1,000;p  < 0.001) 和 0.872 (95% CI 0.765–0.974; p  < 0.001)。心电图变化在出现 MHI 的患者中很常见。就未来可能发生的心律失常事件的进展而言,这些患者需要进行临床随访。

更新日期:2021-06-14
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