Abstract

The effects of the low-temperature plasma exposure, gg irradiation, and combined γ irradiation and plasma exposure on the structure and surface properties of thin films based on polylactic acid (PLA) are studied. Films are prepared by the solvent casting method. It is shown that films based on polylactic acid have topographically different sides: a smoother inner side and an embossed outer one. PLA films have properties close to hydrophobic ones, with a contact angle in the range of 70°–73° regardless of the surface side. They belong to weakly polar materials. The combined effect of plasma and gg irradiation slightly changes the surface topography. The effect of low-temperature plasma on the surface of the films leads to a decrease in the contact angle by 13°–55° (9–11%) and an increase in the surface energy due to the polar component. The results of in vivo experiments on rabbits are presented. Biomicroscopy, optical coherence tomography, and morphological and electron microscopic examination of the cornea after implantation of the initial and radiation- and plasma-treated films show that implantation of the films in the anterior chamber is not accompanied by a pronounced inflammatory reaction and increased intraocular pressure, while maintaining the morphological structure of the cornea almost unchanged.

中文翻译：

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低温等离子体处理和γ辐照对聚乳酸薄膜表面性能的影响

摘要

研究了低温等离子体照射、gg 照射、γ 照射和等离子体照射联合对聚乳酸 (PLA) 薄膜结构和表面性质的影响。薄膜是通过溶剂浇铸法制备的。结果表明，基于聚乳酸的薄膜具有不同的侧面：更光滑的内侧和压花的外侧。PLA 薄膜具有接近疏水性的特性，无论表面如何，接触角都在 70°–73° 范围内。它们属于弱极性材料。等离子体和 gg 辐照的组合效应略微改变了表面形貌。低温等离子体对薄膜表面的影响导致接触角减小 13°–55°（9–11%），并且由于极性成分导致表面能增加。给出了兔体内实验的结果。植入初始和辐射和等离子体处理的薄膜后角膜的生物显微镜、光学相干断层扫描以及形态学和电子显微镜检查表明，在前房中植入薄膜没有伴随明显的炎症反应和眼压升高，同时保持角膜的形态结构几乎不变。