The purpose of this study was to compare the immunohistochemical expression of tenascin-C (Tn-C) regarding clinicopathological variables and its association with the clinical behavior of central giant cell lesions (CGCLs). Forty-eight paraffin-embedded samples of CGCLs were selected. Based on clinical and radiographic features, the lesions were classified as aggressive (A-CGCLs) and non-aggressive (NA-CGCLs) subtypes. Histological assessment included the microvessel count (MVC), multinucleated giant cell (MGC) count, and the proportion of tissue area involved by mononuclear stromal cells/interstitial fibrosis. Immunoreactivity, immunolocalization, and distribution patterns of Tn-C were studied immunohistochemically. The association between Tn-C expression and clinicopathological characteristics was analyzed separately and adjusted for confounders using logistic regression models. A significantly greater proportion of cases with moderate-to-intense, intracellular, and diffuse staining of Tn-C was observed in A-CGCLs. CGCLs with a size ≥3.3 cm, fast growth, cortical disruption, high MVC/MGC counts, and low interstitial fibrosis showed a significantly greater frequency of moderate-to-intense, intracellular, and diffuse staining. Logistic regression analysis indicated a strong/independent association of these three immunohistochemical parameters with the aggressiveness of lesions. These data appear to suggest a possible role for Tn-C in the etiopathogenesis of CGCLs of the jaws, where its upregulation might favor the destructive behavior of A-CGCLs.

本研究的目的是比较生腱蛋白-C (Tn-C) 的免疫组化表达与临床病理学变量及其与中央巨细胞病变 (CGCL) 临床行为的关系。选择了 48 个石蜡包埋的 CGCL 样品。根据临床和影像学特征，病变分为侵袭性（A-CGCLs）和非侵袭性（NA-CGCLs）亚型。组织学评估包括微血管计数 (MVC)、多核巨细胞 (MGC) 计数以及单核基质细胞/间质纤维化所涉及的组织区域的比例。免疫组化研究了 Tn-C 的免疫反应性、免疫定位和分布模式。分别分析 Tn-C 表达与临床病理学特征之间的关联，并使用逻辑回归模型调整混杂因素。在 A-CGCLs 中观察到明显更大比例的 Tn-C 中度至强烈、细胞内和弥漫性染色的病例。大小≥3.3 cm、快速生长、皮质破坏、高 MVC/MGC 计数和低间质纤维化的 CGCL 显示出明显更高的中到强度、细胞内和弥漫性染色频率。逻辑回归分析表明这三个免疫组织化学参数与病变的侵袭性之间存在强/独立的关联。这些数据似乎表明 Tn-C 在颌骨 CGCL 的发病机制中可能发挥作用，其上调可能有利于 A-CGCL 的破坏性行为。